Human CD11c (alpha X integrin) complexes with CD18 (beta 2 integrin) to form the complement receptor type 4 (CR4) heterodimer which binds to fibrinogen and is involved with monocyte/granulocyte adhesion during inflammatory responses (2). CD11c expression is restricted to leukocytes mainly of myeloid lineage with highest expression on macrophages.

Isotype: Murine IgG1

Immunogen: Human rheumatoid synovial fluid cells/monocytes

Specificity: Antibody 3.9 recognizes the human integrin alpha X subunit (CD11c) of about 150 kd (1, 4). It is cross reactive with cynomolgus monkey CD11c (5).

References:

1. N. Hogg, et al, (1986) Eur J Immunol 16: 240-248.

2. S.A. Stacker & T.A. Springer, (1991) J Immunol 146: 648-655.

3. M. Patarroyo, (1994) Immunobiology 191: 474-477.

4. Leukocyte Typing V (1995) (S.F. Schlossman, et al., eds.) Oxford University Press, Oxford,p. 1590-1592.

5. Yoshino N, Honda M, et al. (2000) Exp Anim 49(2):97-110.

Ancell防鼠CD45R（B220）纯化（含抗生素）同种型：  大鼠IgM免疫原：   RAW112细胞信息：抗体RA3-3A1与B220（CD45R）的胞外表位结合，B220是T200的220 kD变异体，存在于B细胞和B细胞前体上。CD45R参与了涉及运动性和枝晶形成的信号传导途径（2）。