mAb name/Clone: ANC10G3

Isotype: Mouse IgG1k

Immunogen: Recombinant human Hif1a

INFORMATION: Hypoxia Inducible Factor 1 alpha (Hif-1a) is a transcription factor which accumulates in the nucleus of cells in most tissues which are subjected to hypoxic conditions. There it stabilizes by associating with Hif-1 beta (ARNT).

Clone ANC10G3 binds to recombinant human Hif-1a in EIA, as well as native HIf1a present in nuclei of fixed permeabolized Nalm-6 cells cultured overnight with CoCl₂ to simulate hypoxia. It interferes with binding of anti-Hif1a clone 546-16, suggesting that their epitopes overlap.

Hif1 References: 1) GL Wang, GL Song, et al. (1993) PNAS 90: 4304

Ancell防鼠CD45R（B220）纯化（含抗生素）同种型：  大鼠IgM免疫原：   RAW112细胞信息：抗体RA3-3A1与B220（CD45R）的胞外表位结合，B220是T200的220 kD变异体，存在于B细胞和B细胞前体上。CD45R参与了涉及运动性和枝晶形成的信号传导途径（2）。