Human CD252 (CD134L, OX40 Ligand) is a type II membrane protein with homology to TNF which is expressed on activated B cells and activated endothelial cells. CD252 binds to CD134(OX40) present on activated T cells, providing a costimulatory signal (1). This pathway seems to be more effective for costimulation of CD4+ helper T cells than for CD8+ effector T cells (4). Blockade of this interaction in mouse abrogated immunological effects in several models of inflammation and rejection (5,6,7,8).

Isotype: Murine IgG1 Kappa

Immunogen: Human HUVEC and Recombinant soluble human CD252

Specificity: Antibody ANC10G1 binds to CD252 on the cell surface of HUVEC in Flow cytometry, and blocks binding of recombinant CD134-muIg.

Functional Application: Antibody ANC10G1 blocks binding of Recombinant CD134 to CD134L on HUVEC.

References:

1) W. R. Godfrey, et al, (1994) J Exp Med 180: 757-763.

2)L.M. Higgins, et al, (1999) J Immunol 162: 486-493.

3) A.D. Weinberg, et al, (1999) J Immunol 162: 1818-1826.

4) V.Y. Taraban, et al, (2002) Eur J. Immunol. 32: 3617-3627.

5) V. Malmstrom, et al, (2001) J Immunol 166: 6972.

6) C. Nohara, et al, (2001) J Immunol 166: 2108-2115.

7) X. Yuan, et al, (2003) J Immunol 170: 2949-2955.

8) L. Tian, et al, (2002) Transplantation 74(1): 133-138.

9) T Uenotsuchi, M Furue, et al. (2006) Intl Immunol 18(12): 1637-1646.

Ancell防鼠CD45R（B220）纯化（含抗生素）同种型：  大鼠IgM免疫原：   RAW112细胞信息：抗体RA3-3A1与B220（CD45R）的胞外表位结合，B220是T200的220 kD变异体，存在于B细胞和B细胞前体上。CD45R参与了涉及运动性和枝晶形成的信号传导途径（2）。