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商品描述
| Product Name | Beta - Amyloid (1 - 16), HumanDAEFRHDSGYEVHHQK |
| Size | 5 mg |
| Catalog # | AS-24226 |
| US$ | $351 |
| Purity | % Peak Area By HPLC ≥ 95% |
Proteins interactions with reactive oxygen agents may result in covalent modifications of amino acid residues in proteins, formation of protein-protein cross-linkages and oxidation of the protein backbone resulting in protein fragmentation. Oxidation targets for Aß (1-16) are the histidine residues coordinated to the metal ions. Copper is bound to Aß in senile plaque of Alzheimers disease with Aß (1-16) taking part in the coordination of the Cu2+ ions. Cu2+ and Zn2+ are linked with the neurotoxicity of Aß and free radical damage. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Da Silva, GFZ. et al. J. Biol. Chem. 280, 16601 (2005); Kowalik-Jankowska, T. et al. J. Inorg. Biochem. 98, 940 (2004); Kowalik-Jankowska, T. et al. J. Inorg. Biochem. 95, 270 (2003). |
| Molecular Weight | 1955 |
| DAEFRHDSGYEVHHQK | |
| Sequence(Three-Letter Code) | H - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - OH |
| Product Citations | Miller, A. et al. (2011). Behavior of β-amyloid 1-16 at the air-water interface at varying pH by nonlinear spectroscopy and molecular dynamics simulations. J Phys Chem 10.1021/jp110103j. Solorzano-Vargas, R.S. et al. (2008). Epitope mapping and neuroprotective properties of a human single chain FV antibody that binds an internal epitope of amyloid-beta 1-42. Mol Immunol 45, 881.Minicozzi, V. et al. (2008). Identifying the minimal Cu and Zn binding site sequence in amyloid beta peptides. J Biol Chem 10.1074/jbc.M707109200.Osada, Y. et al. (2004). CLAC binds to amyloid Peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils. J Biol Chem 280, 8596.Cottingham, MG. et al. (2004). Rapid method for measurement of surface tension in multiwell plates. Lab Methods 84, 523. |
