品牌分类
品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
| Product Name | Prosaptide TX14(A)TaLIDNNATEEILY |
| Size | 5 mg |
| Catalog # | AS-60248-5 |
| US$ | $397 |
| Purity | % Peak Area By HPLC ≥ 95% |
This 14-mer prosaptide sequence is derived from the active neurotrophic region in the amino-terminal portion of the saposin C domain. Synthetic peptides derived from this region are biologically active and are named prosaptides. Prosaposin and prosaptides are active on a variety of neuronal cells, stimulating sulfatide synthesis and increasing sulfatide concentration in Schwann cells and oligodendrocytes. This indicates that prosaposin and prosaptides are trophic factors for myelin formation. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Ref: Campana, M. et al. FASEB J. 12, 307 (1998); Hiraiwa, M. et al. Proc. Natl. Acad. Sci. USA 94, 4778 (1997); Taylor, E. et al. Pharmacol. 295, 190 (2000); Calcutt, NA. et al. Anesthesiology 93, 1271 (2000). |
| Molecular Weight | 1579.7 |
| TaLIDNNATEEILY | |
| Sequence(Three-Letter Code) | H - Thr - D - Ala - Leu - Ile - Asp - Asn - Asn - Ala - Thr - Glu - Glu - Ile - Leu - Tyr - OH |
| Product Citations | Meyer, R. et al. (2013). GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. PNAS 110, 9529.doi: 10.1073/pnas.1219004110.Calcutt, NA. et al. (2000). Protection of sensory function and antihyperalgesic properties of a prosaposin-derived peptide in diabetic rats. Anesthesiology 93, 1271.Otero, D. et al. (1999). Reversal of thermal hyperalgesia in a rat partial sciatic nerve ligation model by Prosaptide TX14(A). Neurosci Lett 270, 29.Campana, WM. et al. (1998). Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells. FASEB J.12, 307. Hiraiwa, M. et al. (1997). Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides. PNAS 94, 4778. |
