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商品描述
| Product Name | Integrin - Binding Site, GRGDNPGRGDNP |
| Size | 1 mg |
| Catalog # | AS-62049 |
| US$ | $63 |
| Purity | % Peak Area By HPLC ≥ 95% |
This RGD-containing sequence is integrin-binding site. RGD peptides are found in both extracellular matrix (ECM) (e.g., collagen, osteopontin, fibronectin, and vitronectin) and non-ECM proteins (e.g., disintegrins). RGD-containing peptides are recognized by several integrins. This peptide targets both alphavbeta3 and alpha5beta1 integrins. Interaction of the RGDN sequence with endothelial alpha5beta1 integrin causes endothelin-mediated arteriolar vasoconstriction. This peptide influences the IkappaB kinase (IKK)/nuclear factor-kappaB (NF-kappaB) activation. It also controls the cardiac contractile function. | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Mogford, J. et al. J. Clin. Invest. 100, 1647 (1997); Sasamoto, A. et al. Am. J. Physiol. Cell. Physiol. 288, C1012 (2005); Sarin, V. et al. J. Physiol. 564, 603 (2005). |
| Molecular Weight | 614.6 |
| GRGDNP | |
| Sequence(Three-Letter Code) | H - Gly - Arg - Gly - Asp - Asn - Pro - OH |
