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商品描述
| Product Name | Ghrelin, rat, mouseGS - S(n - octanoyl) - FLSPEHQKAQQRKESKKPPAKLQPR |
| Size | 5 mg |
| Catalog # | AS-24160 |
| US$ | $997 |
| Purity | % Peak Area By HPLC ≥ 95% |
Rat/mouse Ghrelin differs from human Ghrelin on the 11th and 12th position - RV (Arg-Val) in rat/mouse and KA (Lys-Ala) in human.Ghrelin is an appetite stimulating peptide hormone secreted by stomach P/D1-type cells in humans and circulates in the bloodstream during fasting conditions. Enzymatically n-octanoylated Serine3 of this 28-amino acid Ghrelin is the endogenous ligand specific for growth hormone secretagogue receptor 1a (GHSR1a). The GHSR1a receptor appears to be dedicated to Ghrelin and is widely expressed in different tissues. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Kojima, M. et al. Nature 402, 656 (1999), doi:10.1038/45230Yang J., et. al. Cell 132, 387 (2008).doi: 10.1016/j.cell.2008.01.017 Kojima, M. et. al. Physiol Rev 85, 495 (2005), doi: 10.1152/physrev.00012.2004 Perello, M. & Dickson, SL. J Neuroendocrinol 27, 424 (2015), doi: 10.1111/jne.12236 |
| Molecular Weight | 3314.8 |
| GS-S(n-octanoyl)-FLSPEHQKAQQRKESKKPPAKLQPR | |
| Sequence(Three-Letter Code) | H - Gly - Ser - [Ser(n - octanoyl)] - Phe - Leu - Ser - Pro - Glu - His - Gln - Lys - Ala - Gln - Gln - Arg - Lys - Glu - Ser - Lys - Lys - Pro - Pro - Ala - Lys - Leu - Gln - Pro - Arg - OH |
| Product Citations | Ozfiliz, N. et al. (2011). Effects of different feeding programs and ghrelin injection on plasma ghrelin concentrations and distribution of the ghrelin positive cells in the abomasum of Awassi male lambs. Revue Med Vet 162, 65.Guneli, E. et a. (2010). Effects of repeated administered ghre3lin on chronic constriction injury of the sciatic nerve in rats. Neurosci Lett 479, 226.Granado, M. et al. (2009). Ghrelin treatment protects lactotrophs from apoptosis in the pituitary of diabetic rats. Mol Cell Endocrinol 309, 67.Xu, J. et al. (2009). Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats. Neurosci Lett 453, 58.Waseem, T. et al. (2008). Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways. Surgery 143, 334. Yang, J. et al. (2008). Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132, 387.Barazzoni, R. et al. (2007). Ghrelin enhances in vivo skeletal muscle but not liver AKT signaling in rats. Obesity 15, 2614.Liu, Y. et al. (2006). Ghrelin reduces injury of hippocampal neurons in a rat model of cerebral ischemia/reperfusion. Chin J Physiol 49, 244.Barazzoni, R. et al. (2004). Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle. AJP-Endo Metab 288, E228. |
