Product Name | Z - DEVD - AFC |
Size | 5 mg |
Catalog # | AS-21685-5 |
US$ | $186 |
AFC (7-amino-4-trifluoromethylcoumarin)-derived caspase substrates are widely used for the fluorimetric detection of various caspase activities. Cleavage of AFC peptides by caspases generate strongly fluorescent AFC that is monitored fluorimetrically at 500-510 nm with excitation of 370-390 nm. Caspase-3 and caspase-7 substrates | |
Detailed Information | Material Safety Data Sheets (MSDS) |
Storage | -20°C desiccated and protected from light |
References | Gurtu V, et al. (1997). Fluorometric and colorimetric detection of caspase activity associated with apoptosis. Anal Biochem 251, 98-102; Martins LM, et al. (1997). Activation of multiple interleukin-1beta converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis. J Biol Chem 272, 7421-30; Deveraux QL, et al. (1997). X-linked IAP is a direct inhibitor of cell-death proteases. Nature 388, 300-4;Xiang J, et al. (1996). BAX-induced cell death may not require interleukin 1 ?-converting enzyme-like proteases. Proc Natl Acad Sci USA 93, 14559-63. |
Molecular Weight | 821.6 |
Z-DEVD-AFC | |
Sequence(Three-Letter Code) | z - Asp - Glu - Val - Asp - AFC |