The relationship between cells and their organization within tissue is critical to understanding normal development and disease pathology. The Visium Spatial Gene Expression Solution measures total mRNA in intact tissue sections and maps where gene activity is occurring. This solution provides a high-resolution view of gene expression variability localization as it applies to the study of cancer, neuroscience, developmental biology, and more. Preserving spatial context while identifying distinct groups of cells offers critical information about the relationship of cellular function, phenotype, and location in tissue microenvironments.