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蚂蚁淘在线 / 品牌中心 / Abcam / Abcam/Dyngo® 4a, Novel, highly potent dynamin inhibitor (ab120689)/1/ab120689

Abcam/Dyngo® 4a, Novel, highly potent dynamin inhibitor (ab120689)/1/ab120689

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面议
货号：ab120689
浏览量：127
品牌：Abcam
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商品描述

Overview

  • Product name

    Dyngo® 4a, Novel, highly potentdynamin inhibitor

  • Description

    Novel, highly potent dynamin inhibitor. Dynasore (ab120192) analog.

  • Biological description

    Novel, highly potent dynamin inhibitor (IC50 values are 400 nM and 200 nM at dynamin I and II human-recombinant, respectively). Inhibits clathrin-mediated endocytosis (IC50 = 5.5 µM). Dynasore (ab120192) analog. Prevents botulin neurotoxin A (BoNTs) uptake and internalization, and prevents SNAP25 cleavage. Inhibits BoNTs induced paralysis and delays botulism onset.

  • General notes

    Sold under exclusive licence from Children"s Medical Research Institute and Newcastle Innovation Ltd. Dyngo® is a trademark of Children"s Medical Research Institute and Newcastle Innovation Ltd.

  • CAS Number

    1256493-34-1

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-Hydroxy-N'-[(2,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide

  • Molecular weight

    338.31

  • Molecular formula

    C18H14N2O5

  • PubChem identifier

    136227923

  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in DMSO to 100 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C2C=C(C(=CC2=C1)C(=O)N/N=C/C3=CC(=C(C=C3O)O)O)O

  • Source

    Synthetic

  • Research areas

    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Enzymes
    • ATPase & GTPase
    • Inhibitors
    • Biochemicals
    • Pharmacology
    • Signaling
    • Endocytosis & exocytosis
    • Dynamin
    • Biochemicals
    • Research Area
    • Heart disease
    • Signaling
    • Endocytosis & exocytosis
    • Dynamin
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Signaling
    • Endocytosis & exocytosis
    • Dynamin
    • Biochemicals
    • Research Area
    • Alzheimer"s Disease
    • Signaling
    • Endocytosis & exocytosis
    • Dynamin
    • Biochemicals
    • Research Area
    • Diabetes
    • Signaling
    • Endocytosis & exocytosis
    • Dynamin
    • Biochemicals
    • Research Area
    • Hypertension
    • Signaling
    • Endocytosis & exocytosis
    • Dynamin
    • Biochemicals
    • Research Area
    • Obesity
    • Signaling
    • Endocytosis & exocytosis
    • Dynamin
    • Biochemicals
    • Research Area
    • Respiratory disease
    • Signaling
    • Endocytosis & exocytosis
    • Dynamin
    • Biochemicals
    • Research Area
    • Stroke
    • Signaling
    • Endocytosis & exocytosis
    • Dynamin
Abcam我们的细胞系和裂解物产品组合包括CRISPR敲除，iPSC衍生的神经元，以及来自各种物种和永生化细胞系的标准细胞裂解物，以及健康和患病的组织裂解物。我们所有的细胞系和裂解液均已在关键应用中经过验证，并由abreviews进行了验证。