Overview
Product name
Bafilomycin A1, (V)-ATPase inhibitorDescription
Highly potent, selective (V)-ATPase inhibitorBiological description
Highly potent, selective vacuolar (V)-ATPase inhibitor (IC50 = 500 pM in chromaffin granule membranes). Induces vacuolar deacidification and promotes apoptosis.
CAS Number
88899-55-2Chemical structure
Properties
Chemical name
(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-oneMolecular weight
622.84Molecular formula
C35H58O9PubChem identifier
6436223Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.Solubility overview
Soluble in ethanol to 5mMHandling
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
SMILES
O[C@@]1(C[C@@H](O)[C@H](C)[C@H](O1)C(C)C)[C@@H](C)[C@H](O)[C@H](C)C2OC(=O)C(OC)=CC=C(C)[C@@H](C)[C@@H](O)[C@@H](C)CC(C)=CC=C[C@@H]2OCSource
Streptomyces griseus
Research areas
- Signal Transduction
- Metabolism
- Plasma Membrane
- ATPases
- Biochemicals
- Chemical Type
- Biochemicals
- Biochemicals
- Pharmacology
- Enzymes
- ATPase & GTPase
- Inhibitors
