Transforming growth factor betas (TGFBetas) mediate many cell-cell interactions that occur during embryonic development.Three TGFBetas have been identified in mammals. TGFBeta1,TGFBeta2 and TGFBeta3 are eachsynthesized as precursor proteinsthat are very similar inthat each is cleaved to yield a 112 amino acidpolypeptidethat remains associated with the latentportion of themolecule.TGFB1 Human Recombinantproduced inHuman 293 cells is a homodimeric pol-peptide chaincontaining 2 x 112 amino acids andhaving a totalmolecular mass of 25kDa. The TGFB1is purified byproprietary chromatographic techniques. |