Reconstitution and Storage:Add 200ul of distilled water. Final concentration is 1 mg/ml. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.Gene Symbol:FASAlias Symbols:APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6NCBI Gene Id:355Protein Name:Tumor necrosis factor receptor superfamily member 6Description of Target:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. Swissprot Id:P25445Protein Accession #:NP_690610Nucleotide Accession #:BC012479Molecular Weight:44 Tissue Tool:Find tissues and cell lines supported by DNA array analysis to express FAS. 
RNA Seq:Find tissues and cell lines supported by RNA-seq analysis to express FAS. 
我们在Aviva Systems Biology生产并提供含有重组蛋白或天然蛋白的裂解物，这些蛋白可在Western blot检测中用作阳性对照。重组蛋白在细菌，哺乳动物细胞和昆虫细胞中表达，并作为整体裂解物提供。
