Lysobisphosphatidicacids(LBPAs),knownalsoasbis-(monoacylglycerol)phosphates(BMPs)arespecializedlipidsreportedtoplayaroleinintracellularproteinandlipidtransportinhealthycells.Theiraccumulationwasobservedinpathologiclivertissue,andtheyalsoserveasantigensforauto-antibodygenerationinahumanautoimmuneconditiontermedantiphospholipidsyndrome.AccumulationofLBPAsinintracellular,oftenmultilamellarmembranesisrelatedtobiomembranepolymorphismwhichmayimpactintracellularcholesteroltransport.
(S,S)Bisoleoyl-lysobisphosphatidicacidisthenaturallyoccurring,BIOLOGicallyactivieisomerofLPBA.
Solubility
MeOH:CHCl3(1:1v/v)>1mg/mL
Storage
-20°C
FeaturedinPublications
1)Abe,A,Shayman,J.A.(2009)“TheroleofnegativelychargedlipidsinlysosomalphospholipaseA2function.”JournalofLipidResearch.50(10):2027-35.2)Chevallier,J.etal.(2008)“LysobisphosphatidicAcidControlsEndosomalCholesterolLevels”JournalofBiologicalChemistry.283:27871-278803)Yang,S-T.etal(2010)“Cell-PenetratingPeptideInducesLeakyFusionofliposomesContainingLateEndosome-SpecificAnionicLipid”BiophysicalJournal.8(20):2525–25334)Alvira,D.etal.(2011)“InhibitionofProtein-tyrosinePhosphatase1B(PTP1B)MediatesUbiquitinationandDegradationofBcr-AblProtein”JournalofBiologicalChemistry.286:32313-32323.5)Bissig,C.etal.(2013)“ViralInfectionControlledbyaCalcium-DependentLipid-BindingModuleinALIX”Cell.25(4):364-373.6)Baptist,M.,etal.(2015).“2,2-Bis(monoacylglycero)PO4(BMP),butNot3,1-BMP,IncreasesMembraneCurvatureStresstoEnhanceα-TocopherolTransferProteinBindingtoMembranes.”LipidsJanuary:1-6.
Documents
TechnicalDataSheet
| Categories | Lipids |
|---|---|
| Filter | LBPA,Lysophospholipid |
| CASNumber | 288089-44-1 |
| MolecularFormula | C58H114NO10P |
| MolecularWeight(g/mol) | 1016.5 |
| Purity | >95% |
| Storage | -20°Corbelow |
