NewEast/cAMP [26002-1][30 µL]/26002-1

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¥6600.00
货号:26002-1
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品牌:NewEastBio
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商品描述

CatalogNumber:  26002-1
GeneSymbol:  
Description:  Anti-cAMPMouseMonoclonalAntibody
Background:  cAMPisaubiquitoussecondmessengermediatingcellularresponsestovariousexogenousandendogenoussignalingmolecules.cAMPregulatesphysiologicalprocessesbyactivatingproteinkinases,gatingspecificionchannels,modulatingcellularcyclicnucleotideconcentrationsthroughphosphodiesterases,andactivatingEpac(exchangeproteindirectlyactivatedbycAMP).TheconversionofATPtocAMPiscatalyzedbyadenylylcyclases(ACs).ThemajorfamilyofACsinmammalsisthetransmembraneACswhichhavenineisoformsandcouldbeactivatedbyGproteinGsand/orCa2+/calmodulin.ThereisalsoonesolubleACwhichcouldbemodulatedbybicarbonateand/orCa2+.
Immunogen:  cAMP
Applications:  ELISA,WB,IHC
RecommendedDilutions:  ELISA1:1000-1:5000,WB1:1000-1:2000
Host:  mouse
Format:  Liquid
Clonality:  Monoclonal
Isotype:  IgG
Purity:  Purifiedfromascites
Storagebuffer:
Preservative:  no
Constituents:  PBS(withoutMg2+andCa2+),pH7.4,150mMNaCl,50%glycerol
SpeciesReactivity:  
StorageConditions:  Storeat-20°C.Avoidfreeze/thawcycles
DownloadDatasheet:  
FAQsDatasheet:  
TypicalStandardCurves  
    Sensitivity AcetylatedVersion
MeanODforBo=0.565±0.007
MeanODforStandard#6=0.500±0.006
DeltaOpticalDensity(0-0.08pmol/mL)=0.065
2SD"softheZeroStandard=0.014
Sensitivity=(0.014/0.065)*0.08pmol/mL=17fmol/mL
 
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Publications:
1.  Heterogeneityinrelaxationofdifferentsizedporcinecoronaryarteriestonitrovasodilators:roleofPKGandMYPT1    PflugersArch.2012Feb;463(2):257-68
2.  Antiarrhythmiceffectofprolongedmorphineexposureisaccompaniedbyalteredmyocardialadenylylcyclasesignalinginrats    PharmacolRep.2012;64(2):351-9
3.  UncouplingofM1muscarinicreceptor/G-proteininteractionbyamyloidbeta(1-42)    Neuropharmacology.2013Apr;67:272-83
4.  SubendocardialIncreaseinReactiveOxygenSpeciesProductionAffectsRegionalContractileFunctioninIschemicHeartFailure    AntioxidRedoxSignal.2013Mar20;18(9):1009-20
5.  Heterogeneityinrelaxationofdifferentsizedporcinecoronaryarteriestonitrovasodilators:roleofPKGandMYPT1    PflugersArch.2012Feb;463(2):257-68
6.  Structuralbasisofanthraxedemafactorneutralizationbyaneutralizingantibody    BiochemicalandBiophysicalResearchCommunicationsVolume417,Issue1,6January2012,Pages324–329
7.  TransgenicrescueofdefectiveCd36enhancesmyocardialadenylylcyclasesignalinginspontaneouslyhypertensiverats    PflügersArchiv-EuropeanJournalofPhysiologyOctober2013,Volume465,Issue10,pp1477-1486
8.  OpposingHDAC4nuclearfluxesduetophosphorylationbyβadrenergicactivatedPKAorbyactivityorEpacactivatedCaMKIIinskeletalmusclefibres    TheJournalofPhysiologyVolume591,Issue14,pages3605–3623,July2013
9.  SexisamajordeterminantofneuronaldysfunctioninNeurofibromatosisType1    AnnalsofNeurologyVolume75,Issue2,pages309–316,February2014
10.  cAMP–PKAinhibitionofSK3channelreducedbothCa2+entryandcancercellmigrationbyregulationofSK3–Orai1complex    PflügersArchiv-EuropeanJournalofPhysiologyOctober2014,Volume466,Issue10,pp1921-1932
11.  Immunomodulatingeffectsofcasein-derivedpeptideQEPVLandQEPVonlymphocytesinvitroandinvivo    FoodFunct.,2014,5,2061-2069
12.  AgoNIST-DependentAnd-IndependentDopamine-1-LikeReceptorSignallingDifferentlyRegulatesDownstreamEffectors    FEBSJournalVolume281,Issue21,pages4792–4804,November2014
13.  Alterationofvascularreactivityinheartfailure:Roleofphosphodiesterasestype3and4    BritishJournalofPharmacologyVolume171,Issue23,pages5361–5375,December2014
14.  Ischemia/Reperfusion-InducedCHOPExpressionPromotesApoptosisandImpairsRenalFunctionRecovery:TheRoleofAcidosisandGPR4    PLoSOne.2014Oct24;9(10):e110944
15.  Comparativestudyofsomatostatin-humanserumalbuminfusionproteinsandnaturalsomatostatinonreceptorbinding,internalizationandactivation    PLoSOne.2014Feb27;9(2):e89932