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商品描述
| CatalogNumber: 26136 |
| GeneSymbol: IDH1 |
| Description: Anti-IDH1MouseMonoclonalAntibody |
| Background: Isocitratedehydrogenase(IDH)catalyzestheoxidativedecarboxylationofisocitrateto2-oxoglutarate.MutationsofArg-132inIDHtoCys,His,LeuorSerabolishmagnesiumbindingandtheconversionofisocitratetoalpha-ketoglutarate.Instead,alpha-ketoglutarateisconvertedtoR-2-hydroxyglutarate.ElevatedlevelsofR-2-hydroxyglutaratearecorrelatedwithanelevatedriskofmalignantbraintumors. |
| Immunogen: RecombinantproteinsofhumanIDH1(aminoacids1-240). |
| Applications: ELISA,WB,IHC,IP |
| RecommendedDilutions: ELISA:1:1000-1:5000WB:1:100-1:1000IHC:1:50-1:100 |
| Concentration: 1mg/ml |
| Host: mouse |
| Format: Liquid |
| Clonality: Monoclonal |
| Isotype: IgG |
| Purity: Purifiedfromascites |
| Storagebuffer: |
| Preservative: no |
| Constituents: PBS(withoutMg2+andCa2+),pH7.4,150mMNaCl,50%glycerol |
| SpeciesReactivity: Anti-IDH1antibodyrecognizesIDH1ofvertebrates. |
| StorageConditions: Storeat-20°C.Avoidfreeze/thawcycles |
DownloadDatasheet:  |
| Westernblot: |
| WesternblotanalysisofrecombinantIDH1protein.PurifiedHis-taggedIDH1protein(aminoacids1-240)(Cat.#10198)wasblottedwithanti-IDH1mouseantibody(Cat.#26136). |
| RelatedProducts | |||||
| Catalog# | Name | Size | Price | DataSheet | |
| 26136 | Anti-IDH1MouseMonoclonalAntibody | 100μL | $239 |  | |
| 21277 | Anti-IDH1RabbitPolyclonalAntibody | 100μL | $219 | | |
| 26081 | Anti-IDH1(R132H)MouseMonoclonalAntibody | 100μL | $495 | | |
| 26160 | Anti-IDH1(R132S)MouseMonoclonalAntibody | 100μL | $495 | | |
| 21278 | Anti-IDH2RabbitPolyclonalAntibody | 100μL | $219 | | |
| 26084 | Anti-IDH2(R172H)MouseMonoclonalAntibody | 100μL | $495 | | |
| 26163 | Anti-IDH2(R172K)MouseMonoclonalAntibody | 100μL | $495 | | |
| 26164 | Anti-IDH2(R172W)MouseMonoclonalAntibody | 100μL | $495 | | |
| 26321 | Anti-IDH2(R172G)MouseMonoclonalAntibody | 100μL | $495 | | |
| 26165 | Anti-IDH2(R140Q)MouseMonoclonalAntibody | 100μL | $495 | | |
Publications:| 1. SpecificmonoclonalantibodiesagainstIDH1/2mutationsasdiagnostictoolsforgliomas BrainTumorPathology.January2015,Volume32,Issue1,pp3-11 | 2. MutantIDHinhibitsHNF-4αtoblockhepatocytedifferentiationandpromotebiliarycancer Nature513,110–114(04September2014) | 3. Metabolomiccomparisonbetweencellsoverexpressingisocitratedehydrogenase1and2mutantsandtheeffectsofaninhibitoronthemetabolism JournalofNeuRochemistry.Volume132,Issue2,pages183–193,January2015 | |
