品牌分类
品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
| CatalogNumber: 21001 |
| GeneSymbol: Orai1 |
| Description: Anti-Orai1RabbitPolyclonalAntibody(Orai1-L1) |
| Background: Store-operatedcalciumchannels(SOCs)playessentialfunctionsinvariousphysiologicalprocesses.Orai1(alsonamedCRACM1)isacriticalmolecularcomponentofSOCs.Orai1proteinisa~35kDaplasmamembraneproteinwith4transmembranedomains.Humanpatientswithaseverecombinaedimmunodeficiency(SCID)syndromepossesspointmutationsinOrai1gene. |
| Immunogen: Apeptidefromtheextracellularloop1regionofhumanOrai1 |
| Applications: ELISA,WB,IHC |
| RecommendedDilutions: ELISA: 1:1000-1:5000,WB: 1:1000-1:2000,IHC: 1:100-1:200 |
| Concentration: |
| Host: Rabbit |
| Format: Liquid |
| Clonality: Polyclonal |
| Isotype: IgG |
| Purity: Immunogenaffinitypurified |
| Storagebuffer: |
| Preservative: 0.01%sodiumazide |
| Constituents: 50mMNaHCO3-Glycine,0.15MNaCl,pH7.4 |
| SpeciesReactivity: Orai1-L1antibodyrecognizesOrai1fromhumanandmouse.ItmayalsorecognizeOrai2andOrai3. |
| StorageConditions: Storeat-20°C.Avoidfreeze/thawcycles |
DownloadDatasheet:  |
| Westernblot: |
| WesternblotanalysisofOrai1protein.HumanOrai1plasmidDNAwastransientlytransfectedintoHEK-293cells.Whole-celllysatewasusedforwesternblotintheabsence(lane1)orpresence(lane2)ofantigenpeptide. | |||||
| Immunohistochemistry | ||||||
 | ImmunohistochemistryofendogenousOrai1inNIH3T3cellsshowingtheplasmamembranestaining. | |||||
| RelatedProducts | |||||
| Catalog# | Name | Size | Price | DataSheet | |
| 21001 | Anti-Orai1RabbitPolyclonalAntibody(Orai1-L1) | 100μL | $219 |  | |
| 21002 | Anti-Orai1RabbitPolyclonalAntibody(Orai1-L2) | 100μL | $219 | | |
Publications:| 1. GenerationandCharacterizationofFullyHumanMonoclonalAntibodiesAgainstHumanOrai1forAutoimmuneDisease JPharmacolExpTher.2013May;345(2):225-38 | 2. InfluenceofOrai1interventiononmouseairwayepitheliumreactionsinvivoandinvitro AnnAllergyAsthmaImmunol.2012Feb;108(2):103-12 | 3. 2-AminoethoxydiphenylborateadmiNISTrationintothenostrilalleviatesmurineallergicrhinitis AmJOtolaryngol.2011Jul-Aug;32(4):318-28 | 4. Up-regulationofOrai1inmurineallergicrhinitis HistochemCellBiol.2010Jul;134(1):93-102 | 5. Orai1andSTIM1arecriticalforbreasttumorcellmigrationandmetastasis CancerCell.2009Feb3;15(2):124-34 | 6. AmeliorationofMuc5bmucinhypersecretionisenhancedbyIL-33after2-APBadministrationinamurinemodelofallergicrhinitis BiotechHistochem.2014May;89(4):273-86 | |
