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商品描述
| CatalogNumber: 21237 |
| GeneSymbol: SUMO2/3 |
| Description: Anti-SUMO-2/3RabbitpolyclonalAntibody |
| Background: SmallUbiquitin-likeModifierorSUMOproteinsareafamilyofsmallproteinsthatarecovalentlyattachedtoanddetachedfromotherproteinsincellstomodifytheirfunction.SUMOylationisapost-translationalmodificationinvolvedinvariouscellularprocesses,suchasnuclear-cytosolictransport,transcriptionalregulation,apoptosis,proteinstABIlity,responsetostress,andprogressionthroughthecellcycle.Thereare3confirmedSUMOisoformsinhumans:SUMO-1,SUMO-2andSUMO-3.SUMO-2and-3showahighdegreeofsimilaritytoeachotherandaredistinctfromSUMO-1. |
| Immunogen: AsyntheticpeptidecorrespondingtoresiduesneartheC-terminalofhumanSUMO-2/3. |
| Applications: ELISA,WB,IHC,IP |
| RecommendedDilutions: ELISA:1:1000-1:5000WB:1:100-1:1000IHC:1:50-1:100 |
| Concentration: 1mg/ml |
| Host: Rabbit |
| Format: Liquid |
| Clonality: Polyclonal |
| Isotype: |
| Purity: Purifiedfromserum |
| Storagebuffer: |
| Preservative: no |
| Constituents: PBS(withoutMg2+andCa2+),pH7.4,150mMNaCl,50%glycerol |
| SpeciesReactivity: DetectsSUMO-2/3butnotSUMO-1fromvertebrates. |
| StorageConditions: Storeat-20°C.Avoidfreeze/thawcycles |
DownloadDatasheet:  |
| Westernblot: |
| Westernblotanalysisofover-expressedSUMO-2andSUMO-3proteins.HEK293cellsweretransfectedwithSUMO-2(lane2)andSUMO-3(lane3)CDNAsandcontrolemptyvector(lane1).Celllysateswereblottedwithanti-SUMO-2/3rabbitpolyclonalantibody(Cat.#21237). |
| RelatedProducts | |||||
| Catalog# | Name | Size | Price | DataSheet | |
| 21236 | Anti-SUMO-1RabbitpolyclonalAntibody | 100μL | $219 |  | |
| 21237 | Anti-SUMO-2/3RabbitpolyclonalAntibody | 100μL | $219 | | |
Publications:| 1. TheSUMOylationofzinc-fingersandhomeoboxes1(ZHX1)byUbc9regulatesitsstabilityandtranscriptionalrepressionactivity JournalofCellularBiochemistryVolume114,Issue10,pages2323–2333,October2013 | 2. C-terminalSrcKinase(Csk)-mediatedPhosphorylationofEukaryoticElongationFactor2(eEF2)PromotesProteolyticCleavageandNuclearTranslocationofeEF2 JBiolChem.2014May2;289(18):12666-78 | |
