Description

JenKem Technology’s Methoxy PEG Succinimidyl Propionate (Methoxy PEG Succinimidyl Propanoate, Methoxy PEG SPA, mPEG-SPA, or M-PEG SPA) is a high quality amine reactive NHS PEG product with a stable non-degradable linker between the PEG polymeric chain and the NHS ester. Methoxy PEG Succinimidyl Propionate reacts with the amine group of lysine(s), such as those on on HGH antagonist, growth hormone B2036, granulocyte colony stimulating factor MAXY-G34 (CSF MAXY-G34) [5], or uricase. Methoxy PEG Succinimidyl Propionate has a longer hydrolysis half-life compared with M-PEG-SCM.

JenKem Technology offers Methoxy PEG SPA with MW 5000 Da (M-SPA-5000), MW 10000 Da (M-SPA-10K), MW 20000 Da (M-SPA-20K), MW 30000 Da (M-SPA-30K), MW 40000 Da (M-SPA-40K) in 1g and 10g packing sizes. Different MW of Methoxy PEG SPA products may be available by custom synthesis, please email us at tech@jenkemusa.com for details on custom PEGs. Other linear JenKem NHS ester PEGs are available – if interested please select stable linker NHS PEGs, carbonate linker stable NHS PEGs, or cleavable linker NHS PEGs. JenKem Technology provides repackaging services for an additional fee, please contact us if you require a different package size than our catalog selection.

Bulk PEGs and GMP grade PEGs are made-to-order. Please contact us for bulk pricing.

References:

1. Pfister, D., et al., Model-based development of an on-column PEGylation process, React. Chem. Eng., 2016.

2. Ingold, O., et al., A reactive continuous chromatographic process for protein PEGylation, React. Chem. Eng., 2016.

3. Pfister, D., et al., Integrated process for high conversion and high yield protein PEGylation, Biotechnol. Bioeng., 2016.

4. Goffin V, et al., Pegvisomant Pfizer/Sensus. Curr Opin Investig Drugs, 2004, 5:463–468.

5. https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C71718.

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.

JenKem用于胺聚乙二醇化的活化PEGJenKem Technology生产具有NHS和羧基官能度，高纯度和低多分散性的用于胺PEG化的高质量活化PEG。在结构上，JenKem Technology提供胺反应性线性PEG，Y形PEG，U形PEG，多臂PEG和单分散PEG。JenKem Technology专有的Y形支化PEG衍生物的空间庞大结构，由两个连接在具有活性NHS基团的中心核上的线性甲氧基PEG链组成，可能有助于减少蛋白质分子的附着位点数量。具有稳定连接子的PEG NHS酯：MPEG-SCM，MPEG-SPA，MPEG-SBA，MPEG-SHA，MPEG-SGA，MPEG-SSA，SCM-PEG-SCM，Y-PEG-NHS，MPEG2-LYS-PEG-NHS ，GLUC-PEG-NHS，GALA-PEG-NHS带有碳酸酯连接基的PEG产品：MPEG-SC，MPEG-NPC具有可裂解NHS酯连接基的可降解PEG：MPEG-SS，SS-PEG-SS和MPEG-SGPEG羧基：Y-PEG-COOH，MPEG-CM，MPEG-PA，MPEG5-PA，MPEG6-PA，MPEG-BA，MPEG-HA –比NHS PEG稳定。使用JenKem®Y-PEG-NHS进行蛋白质PEG化的示意图分子量，支链和官能团未在我们的在线目录中列出的胺PEG化产品可通过定制合成以及PEG化服务获得。JenKem Technology通过定制合成提供GMP级PEG衍生物和批量订单，从而有机会满足客户的特殊质量要求。根据ICH Q7A准则，JenKem Technology能够根据ISO 9001和ISO 13485认证的质量管理体系，以200g至40kg或更大的批次开发和合成各种GMP PEG衍生物。2020年，JenKem Technology将过渡为使用  高纯度（> 99％）mPEG  原料生产GMP级甲氧基PEG衍生物。