Description

Methoxy PEG Succinimidyl Carbonate for amine PEGylation, with superior quality specification of  ≥95% Substitution.

JenKem Technology’s Methoxy PEG Succinimidyl Carbonate (Methoxy PEG SC) is a high quality amine reactive NHS PEG product which reacts with the amine group of lysine(s) such as the lysines present on IFN, Interferon alpha 2b, by means of stable urethane linkages. Methoxy PEG Succinimidyl Carbonate has a longer hydrolysis half-life compared with M-PEG-SCM. JenKem Technology offers Methoxy PEG Succinimidyl Carbonate with MW 10000 Da (M-SC-10K), MW 12000 (M-SC-12K), and MW 20000 Da (M-SC-20K), in 1g and 10g packing sizes.

Different MW of Methoxy PEG Succinimidyl Carbonate products may be available by custom synthesis, please email us at tech@jenkemusa.com for details on custom PEGs. Other related linear Amine Reactive PEG products are available – please select linear carbonate PEGs;  cleavable linker NHS PEGs; or stable linker NHS PEGs. JenKem Technology provides repackaging services for an additional fee, please contact us if you require a different package size than our catalog selection.

Bulk PEGs and GMP grade PEGs are made-to-order. Please contact us for bulk pricing.

Click here to download the MSDS

References:

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4. Vaillard, V.A., et al., mPEG–NHS carbonates: Effect of alkyl spacers on the reactivity: Kinetic and mechanistic insights, Journal of Applied Polymer Science, 2019, 136(5):47028.
5. Ma, S.S., et al., The pharmacokinetic and pharmacodynamic properties of site-specific pegylated genetically modified recombinant human interleukin-11 in normal and thrombocytopenic monkeys, European Journal of Pharmaceutics and Biopharmaceutics, 2017.
6. Zhao, Y.Z., et al., PEGylation with the thiosuccinimido butylamine linker significantly increases the stability of haloalkane dehalogenase DhaA, Journal of Biotechnology, 2017.
7. Lee, K., et al., Enhanced accumulation of theranostic nanoparticles in brain tumor by external magnetic field mediated in situ clustering of magnetic nanoparticles, Journal of Industrial and Engineering Chemistry, 2017.
8. Wan, X., et al., Effect of protein immunogenicity and PEG size and branching on the anti-PEG immune response to PEGylated proteins, Process Biochemistry, 2017, 52:183-91.
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10. Zhang, J., et al., Magnetic Targeting of Novel Heparinized Iron Oxide Nanoparticles Evaluated in a 9L-glioma Mouse Model, Pharmaceutical Research, 2014, 31:3, pp 579-592.
11. Peng, F., et al., PEGylation of G-CSF in organic solvent markedly increase the efficacy and reactivity through protein unfolding, hydrolysis inhibition and solvent effect. Journal of Biotechnology, 2014, 170: p. 42-49.
12. Mingji Jin, et al, Preparation of pegylated lumbrokinase and an evaluation of its thrombolytic activity both in vitro and in vivo, Acta Pharmaceutica Sinica B, 2013, 3(2) p: 123-129.
13. Zhang, J., et al., Long-Circulating Heparin-Functionalized Magnetic Nanoparticles for Potential Application as a Protein Drug Delivery Platform, Molecular Pharmaceutics, 2013, 10(10), 3892-3902.
14. Jun Wang, et al., An oriented adsorption strategy for efficient solid phase PEGylation of recombinant staphylokinase by immobilized metal-ion affinity chromatography, Process Biochemistry, 2012, 47, 1,  p: 106-112.
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Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization directly from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.

JenKem用于胺聚乙二醇化的活化PEGJenKem Technology生产具有NHS和羧基官能度，高纯度和低多分散性的用于胺PEG化的高质量活化PEG。在结构上，JenKem Technology提供胺反应性线性PEG，Y形PEG，U形PEG，多臂PEG和单分散PEG。JenKem Technology专有的Y形支化PEG衍生物的空间庞大结构，由两个连接在具有活性NHS基团的中心核上的线性甲氧基PEG链组成，可能有助于减少蛋白质分子的附着位点数量。具有稳定连接子的PEG NHS酯：MPEG-SCM，MPEG-SPA，MPEG-SBA，MPEG-SHA，MPEG-SGA，MPEG-SSA，SCM-PEG-SCM，Y-PEG-NHS，MPEG2-LYS-PEG-NHS ，GLUC-PEG-NHS，GALA-PEG-NHS带有碳酸酯连接基的PEG产品：MPEG-SC，MPEG-NPC具有可裂解NHS酯连接基的可降解PEG：MPEG-SS，SS-PEG-SS和MPEG-SGPEG羧基：Y-PEG-COOH，MPEG-CM，MPEG-PA，MPEG5-PA，MPEG6-PA，MPEG-BA，MPEG-HA –比NHS PEG稳定。使用JenKem®Y-PEG-NHS进行蛋白质PEG化的示意图分子量，支链和官能团未在我们的在线目录中列出的胺PEG化产品可通过定制合成以及PEG化服务获得。JenKem Technology通过定制合成提供GMP级PEG衍生物和批量订单，从而有机会满足客户的特殊质量要求。根据ICH Q7A准则，JenKem Technology能够根据ISO 9001和ISO 13485认证的质量管理体系，以200g至40kg或更大的批次开发和合成各种GMP PEG衍生物。2020年，JenKem Technology将过渡为使用  高纯度（> 99％）mPEG  原料生产GMP级甲氧基PEG衍生物。