Description

MethoxyPEGSuccinimidylSuccinatewithsuperiorqualityspecificationof ≥95%Substitution.

JenKemTechnology’sMethoxyPEGSuccinimidylSuccinate (MethoxyPEGSS)isahighqualityaminereactiveNHSPEGproductwithdegradablecleavableesterlinkerbetweenthePEGpolymericchainandtheNHSester.LinearNHSPEGswithCleavableLinker(degradablePEGs)areespeciallyemployed incontrolledreleasedrugdevelopmentapplications.MethoxyPEGSuccinimidylSuccinate reactswiththeaminegroupoflysine(s),or aminessuchasontheactiveingredientsofAdagen®,Peg-ademase,orPEG-adenosinedeaminase,PEGaspargase,PEG-L-asparaginase, orrelatedbiosimilars,atpH7-8,whiletheesterlinkageiscleavedunderregularestercleavingreactionconditions.JenKemTechnologyoffersMethoxyPEGSS withMW5000Da(M-SS-5000)andMW20000Da(M-SS-20K),in1gand10gpackingsizes.

DifferentMWofMethoxyPEGSuccinimidylSuccinateproductsmaybeavailablebycustomsynthesis,pleaseemailus attech@jenkemusa.comfordetailsoncustomPEGs.OtherlinearNHSestersareavailable–pleaseselectother cleavablelinkerNHSPEGs; or stablelinkerNHSPEGs.JenKemTechnology providesrepackagingservicesforanadditionalfee,pleasecontactusifyourequireadifferentpackagesizethanourcatalogselection.

BulkPEGsandGMPgradePEGsaremade-to-order.Pleasecontactus forbulkpricing.

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References:

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2.Mastorakos,P.,etal.,Biodegradablebrain-penetratingDNAnanocomplexesandtheirusetotreatmalignantbraintumors,JournalofControlledRelease,2017,262,P.37-46.

3.Mastorakos,P.,etal., BiodegradableDNANanoparticlesthatProvideWidespreadGeneDeliveryintheBrain,Small,2015.

4. Jain,S.,etal.,Combinatorialbio-conjugationofgemcitABIneandcurcuminenablesdualdrugdeliverywithsynergisticanticancerefficacyandreducedtoxicity, RSCAdv.,2014,4,29193-29201.

5.Tesfay,M.Z.,etal.,PEGylationofvesicularstomatitisvirusextendsviruspersistenceinbloodcirculationofpassivelyimmunizedmice.JVirol,2013,87(7):p.3752-9.

6. Helgeson,L.A.,etal,MechanismofsynergisticactivationofArp2/3complexbycortactinandN-WASP, eLife,2013,2:e00884.

7. Depp,V.,etal.,Nativeprotein-initiatedATRP:AviableandpotentiallysuperioralternativetoPEGylationforstabilizingBIOLOGics,ActaBiomaterialia,5(2),2009,p: 560-569.

Foundedin2001byexpertsinPEGsynthesisandPEGylation,JenKemTechnologyspecializesexclusivelyinthedevelopmentandmanufacturingofhighqualitypolyethyleneglycol(PEG)productsandderivatives,andrelatedcustomsynthesisandPEGylationservices.JenKemTechnologyisISO9001andISO13485certified,andadherestoICHQ7AguidelinesforGMPmanufacture.TheproductionofJenKem®PEGsisback-integratedtoin-housepolymerizationfromethyleneoxide,enablingfaciletraceabilityforregulatedcustomers.JenKemTechnologycaterstothePEGylationneedsofthepharmaceutical,biotechnology,medicaldeviceanddiagnostics,andemergingchemicalspecialtymarkets,fromlaboratoryscalethroughlargecommercialscale.

JenKem用于胺聚乙二醇化的活化PEGJenKem Technology生产具有NHS和羧基官能度，高纯度和低多分散性的用于胺PEG化的高质量活化PEG。在结构上，JenKem Technology提供胺反应性线性PEG，Y形PEG，U形PEG，多臂PEG和单分散PEG。JenKem Technology专有的Y形支化PEG衍生物的空间庞大结构，由两个连接在具有活性NHS基团的中心核上的线性甲氧基PEG链组成，可能有助于减少蛋白质分子的附着位点数量。具有稳定连接子的PEG NHS酯：MPEG-SCM，MPEG-SPA，MPEG-SBA，MPEG-SHA，MPEG-SGA，MPEG-SSA，SCM-PEG-SCM，Y-PEG-NHS，MPEG2-LYS-PEG-NHS ，GLUC-PEG-NHS，GALA-PEG-NHS带有碳酸酯连接基的PEG产品：MPEG-SC，MPEG-NPC具有可裂解NHS酯连接基的可降解PEG：MPEG-SS，SS-PEG-SS和MPEG-SGPEG羧基：Y-PEG-COOH，MPEG-CM，MPEG-PA，MPEG5-PA，MPEG6-PA，MPEG-BA，MPEG-HA –比NHS PEG稳定。使用JenKem®Y-PEG-NHS进行蛋白质PEG化的示意图分子量，支链和官能团未在我们的在线目录中列出的胺PEG化产品可通过定制合成以及PEG化服务获得。JenKem Technology通过定制合成提供GMP级PEG衍生物和批量订单，从而有机会满足客户的特殊质量要求。根据ICH Q7A准则，JenKem Technology能够根据ISO 9001和ISO 13485认证的质量管理体系，以200g至40kg或更大的批次开发和合成各种GMP PEG衍生物。2020年，JenKem Technology将过渡为使用  高纯度（> 99％）mPEG  原料生产GMP级甲氧基PEG衍生物。