Description

PEG(AceticAcid)2(PEGdi-aceticacidorPEGdicarboxyl)withsuperiorqualityspecificationof ≥95%Substitution.

PEG(AceticAcid)2fromJenKemTechnologyisahomobifunctionalPEGemployedforaminepegylationandcrosslinking,reactivetowardstheaminegroupoflysine(s).HomobifunctionalPEGderivativesfrom JenKemTechnologyhavenumerousapplicationsascrosslinkersforPEGylationofproteinsandpeptides,nanoparticleandsurfacemodifications.ConjugationwithhomobifunctionalPEGsensures anincreaseddrugloadcomparedtopegylationwith linearPEGs.JenKemTechnologyoffersAceticAcidPEGAceticAcidwithMW2,000Da(CM-PEG2000-CM),MW3,500Da(CM-PEG3500-CM),MW5,000Da(CM-PEG5000-CM),andMW7,500Da(CM-PEG7500-CM),in1gand5gpackingsizes.

DifferentMWof PEG(AceticAcid)2maybeavailablebycustomsynthesis,pleaseemailus attech@jenkemusa.comfordetailsoncustomPEGs. JenKemTechnology providesrepackagingservicesforanadditionalfee,pleasecontactusifyourequireadifferentpackagesizethanourcatalogselection.

BulkPEGsandGMPgradePEGsaremade-to-order.Pleasecontactusforbulkpricing.

Note:StartingJuly2016, PEG(AceticAcid)2isthenewnameoftheproductCarboxylPEGCarboxyl(MW2000Da(COOH-PEG2000-COOH),MW3500Da(COOH-PEG3500-COOH),MW5,000Da(COOH-PEG5000-COOH),andMW7500Da(COOH-PEG7500-COOH);orPEGDicarboxyl.JenKemTechnologyhasrevisedthenameoftheproducttobetterreflectthechemical structure,asmanyotherPEGderivativeswithCOOHgroup areofferedinthecatalog.

References:

1. Ji,F.,etal.,ADualpH/MagneticResponsiveNanocarrierBasedonPEGylatedFe3O4NanoparticlesforDoxorubicinDelivery,JournalofNanoscienceandNanotechnology,2018,18.7:4464-4470.

2.Xiao,S.,etal.,Aptamer-mediatedgenetherapyenhancedantitumoractivityagainsthumanhepatocellularcarcinomainvitroandinvivo,JournalofControlledRelease,2017.

3.Jing,P.,etal,Enhancedgrowthinhibitionofprostatecancerinvitroandinvivobyarecombinantadenovirus-mediateddual-aptamermodifieddrugdeliverysystem,CancerLetters,2016,V.383(2),P.230-242.

4.Lorenzo,M.M.,etal., HomodimericProtein–PolymerConjugatesviatheTetrazine–trans-CycloocteneLigation,Macromolecules,2015.

5. Xue,Y.,etal., Quantifyingthiol–goldinteractionstowardstheefficientstrengthcontrol,Naturecommunications,2014,5.

6.Xu,P.,etal.,Hydrogen-bondedandreduction-responsivemicellesloADIngatorvastatinfortherapyofbreastcancermetastasis.Biomaterials,2014,35(26):p.7574-7587.

7.Gajbhiye,V.,etal.,Drug-loadednanoparticlesinducegeneexpressioninhumanpluripotentstemcellderivatives.Nanoscale,2014,6(1):p.521-31.

8.Gao,X.,etal.,Prostatestemcellantigen-targetednanoparticleswithdualfunctionalproperties:invivoimagingandcancerchemotherapy.IntJNanomedicine,2012,7:p.4037-51.

Foundedin2001byexpertsinPEGsynthesisandPEGylation,JenKemTechnologyspecializesexclusivelyinthedevelopmentandmanufacturingofhighqualitypolyethyleneglycol(PEG)productsandderivatives,andrelatedcustomsynthesisandPEGylationservices.JenKemTechnologyisISO9001andISO13485certified,andadherestoICHQ7AguidelinesforGMPmanufacture.TheproductionofJenKem®PEGsisback-integratedtoin-housepolymerizationfromethyleneoxide,enablingfaciletraceABIlityforregulatedcustomers.JenKemTechnologycaterstothePEGylationneedsofthepharmaceutical,biotechnology,medicaldeviceanddiagnostics,andemergingchemicalspecialtymarkets,fromlaboratoryscalethroughlargecommercialscale.

JenKem用于胺聚乙二醇化的活化PEGJenKem Technology生产具有NHS和羧基官能度，高纯度和低多分散性的用于胺PEG化的高质量活化PEG。在结构上，JenKem Technology提供胺反应性线性PEG，Y形PEG，U形PEG，多臂PEG和单分散PEG。JenKem Technology专有的Y形支化PEG衍生物的空间庞大结构，由两个连接在具有活性NHS基团的中心核上的线性甲氧基PEG链组成，可能有助于减少蛋白质分子的附着位点数量。具有稳定连接子的PEG NHS酯：MPEG-SCM，MPEG-SPA，MPEG-SBA，MPEG-SHA，MPEG-SGA，MPEG-SSA，SCM-PEG-SCM，Y-PEG-NHS，MPEG2-LYS-PEG-NHS ，GLUC-PEG-NHS，GALA-PEG-NHS带有碳酸酯连接基的PEG产品：MPEG-SC，MPEG-NPC具有可裂解NHS酯连接基的可降解PEG：MPEG-SS，SS-PEG-SS和MPEG-SGPEG羧基：Y-PEG-COOH，MPEG-CM，MPEG-PA，MPEG5-PA，MPEG6-PA，MPEG-BA，MPEG-HA –比NHS PEG稳定。使用JenKem®Y-PEG-NHS进行蛋白质PEG化的示意图分子量，支链和官能团未在我们的在线目录中列出的胺PEG化产品可通过定制合成以及PEG化服务获得。JenKem Technology通过定制合成提供GMP级PEG衍生物和批量订单，从而有机会满足客户的特殊质量要求。根据ICH Q7A准则，JenKem Technology能够根据ISO 9001和ISO 13485认证的质量管理体系，以200g至40kg或更大的批次开发和合成各种GMP PEG衍生物。2020年，JenKem Technology将过渡为使用  高纯度（> 99％）mPEG  原料生产GMP级甲氧基PEG衍生物。