Description

JenKemTechnology’s MethoxyPEGSuccinimidylPropionate (MethoxyPEGSuccinimidylPropanoate,MethoxyPEGSPA,mPEG-SPA,orM-PEGSPA)isahighqualityaminereactiveNHSPEGproductwitha stablenon-degradablelinkerbetweenthePEGpolymericchainandtheNHSester.MethoxyPEGSuccinimidylPropionate reactswiththeaminegroupoflysine(s),suchasaminesontheactiveingredientsofSomavert®,PEG-HGHantagoNIST,Pegvisomant,PeggrowthhormoneB2036[4],pegylatedgranulocytecolonystimulatingfactorMAXY-G34(PEG-CSFMAXY-G34)[5],orPuricasePEG-uricase,Pegloticase,orKrystexxya®,andrelatedbiosimilars.MethoxyPEGSuccinimidylPropionate hasa longerhydrolysishalf-lifecomparedwithM-PEG-SCM.

JenKemTechnologyoffersMethoxyPEGSPA withMW5000Da(M-SPA-5000),MW10000Da(M-SPA-10K),MW20000Da(M-SPA-20K),MW30000Da(M-SPA-30K),MW40000Da(M-SPA-40K)in1gand10gpackingsizes. DifferentMWofMethoxyPEGSPA productsmaybeavailablebycustomsynthesis,pleaseemailus attech@jenkemusa.comfordetailsoncustomPEGs.OtherlinearJenKemNHSesterPEGsareavailable–ifinterestedpleaseselectstablelinkerNHSPEGs,carbonatelinkerstableNHSPEGs,or cleavablelinkerNHSPEGs.JenKemTechnology providesrepackagingservicesforanadditionalfee,pleasecontactusifyourequireadifferentpackagesizethanourcatalogselection.

BulkPEGsandGMPgradePEGsaremade-to-order.Please contactus forbulkpricing.

References:

1.Pfister,D.,etal.,Model-baseddevelopmentofanon-columnPEGylationprocess, React.Chem.Eng.,2016.

2. Ingold,O.,etal.,AreactivecontinuouschromatographicprocessforproteinPEGylation, React.Chem.Eng.,2016.

3. Pfister,D.,etal.,IntegratedprocessforhighconversionandhighyieldproteinPEGylation,Biotechnol.Bioeng., 2016.

4. GoffinV,etal., PegvisomantPfizer/Sensus.CurrOpinInvestigDrugs,2004,5:463–468.

5. https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C71718.

Foundedin2001byexpertsinPEGsynthesisandPEGylation,JenKemTechnologyspecializesexclusivelyinthedevelopmentandmanufacturingofhighqualitypolyethyleneglycol(PEG)productsandderivatives,andrelatedcustomsynthesisandPEGylationservices.JenKemTechnologyisISO9001andISO13485certified,andadherestoICHQ7AguidelinesforGMPmanufacture.TheproductionofJenKem®PEGsisback-integratedtoin-housepolymerizationfromethyleneoxide,enablingfaciletraceABIlityforregulatedcustomers.JenKemTechnologycaterstothePEGylationneedsofthepharmaceutical,biotechnology,medicaldeviceanddiagnostics,andemergingchemicalspecialtymarkets,fromlaboratoryscalethroughlargecommercialscale.

JenKem用于胺聚乙二醇化的活化PEGJenKem Technology生产具有NHS和羧基官能度，高纯度和低多分散性的用于胺PEG化的高质量活化PEG。在结构上，JenKem Technology提供胺反应性线性PEG，Y形PEG，U形PEG，多臂PEG和单分散PEG。JenKem Technology专有的Y形支化PEG衍生物的空间庞大结构，由两个连接在具有活性NHS基团的中心核上的线性甲氧基PEG链组成，可能有助于减少蛋白质分子的附着位点数量。具有稳定连接子的PEG NHS酯：MPEG-SCM，MPEG-SPA，MPEG-SBA，MPEG-SHA，MPEG-SGA，MPEG-SSA，SCM-PEG-SCM，Y-PEG-NHS，MPEG2-LYS-PEG-NHS ，GLUC-PEG-NHS，GALA-PEG-NHS带有碳酸酯连接基的PEG产品：MPEG-SC，MPEG-NPC具有可裂解NHS酯连接基的可降解PEG：MPEG-SS，SS-PEG-SS和MPEG-SGPEG羧基：Y-PEG-COOH，MPEG-CM，MPEG-PA，MPEG5-PA，MPEG6-PA，MPEG-BA，MPEG-HA –比NHS PEG稳定。使用JenKem®Y-PEG-NHS进行蛋白质PEG化的示意图分子量，支链和官能团未在我们的在线目录中列出的胺PEG化产品可通过定制合成以及PEG化服务获得。JenKem Technology通过定制合成提供GMP级PEG衍生物和批量订单，从而有机会满足客户的特殊质量要求。根据ICH Q7A准则，JenKem Technology能够根据ISO 9001和ISO 13485认证的质量管理体系，以200g至40kg或更大的批次开发和合成各种GMP PEG衍生物。2020年，JenKem Technology将过渡为使用  高纯度（> 99％）mPEG  原料生产GMP级甲氧基PEG衍生物。