Plain liposomes are extensively used as artificial cell models and for studying the interaction of various types of molecules such as peptides and proteins with the surface of the lipid membranes. Plain liposomes are also used as control formulations for many different types of drug encapsulated liposome formulations. Charged liposomes are also used in many different types of blood complement studies. Plain liposomes are available in various anionic, cationic and neutral surface charges. Plain liposomes can be unilamellar or multilamellar.

Phosphatidylserine (PS) and phosphatidylglycerol (PG) are two well-known anionic molecules that form liposomes with negative zeta potential. The zeta potential of the liposomes varies depending on the molar percentage of the negatively charged lipids in the liposome formulation. Anionic Cellsome®-Phosphatidylserine (PS) and Cellsome®-Phosphatidylglycerol (PG) catalogs contain the products made from 0.5 up to 100 percent DOPS and DOPG, respectively, with various amount of negative zeta potentials.