Description
Tauisafamilyofsixisoforms,derivedfromasinglegenebyalternativemRNAsplicing
1.Theyvaryinsizefrom352to441aminoacids(36.8to45.9kDa),anddifferfromoneanotherinhavingthreeorfourmicrotubulebindingrepeats
(R)of31-32aminoacidseach,andtwo,oneornoneaminoterminalinserts
(N)of29aminoacidseach2.
Taupromotestheassemblyandmaintainsthestructureofmicrotubulesinneuronalcells3,4,5.Whilethefetalbraincontainsasingleisoformoftau(Tau-352)theadultbrainhasseveralisoforms.TauisbothphosphorylatedandO-GlcNAcylated6.Thenormalbraintaucontains2-3molesofphosphate/moleoftheprotein.InAlzheimerdiseasetauishyperphosphorylated,containing3-4-foldmorephosphate/moleoftheproteinthanthenormaltau7,8andisthemajorproteinsubunitofpairedhelicalfilaments(PHF)thatformtheneurofibrillarytangles(NFT).NFTaccumulationcorrelateswiththeclinicalprogressionofAlzheimer"sdisease.Tau4G11(TA-1001)isarPeptideexclusiveTauMonoclonalAntibodythatbinds4outofthe6Tauisoforms.ItspecificallybindsTau-381,Tau-410,Tau-412,andTau-441whichallcontainatleastoneaminoterminalinsert.
用产品只提供给进一步的科研使用,不可应用于治疗等其他方面。
rPeptide是设在雅典,美国佐治亚州的一家生物技术公司,是一种在阿尔茨海默氏症和帕金森氏病的研究提供研究产品(重组多肽和蛋白质,抗体,试剂)市场的*。rPeptide还提供定制服务的范围从分子生物学,蛋白表达和纯化,13C和15N的多肽和蛋白质的统一标识。 rPeptide有一个专有的平台载体技术,使可溶性肽/蛋白在大肠杆菌中(如淀,β-淀粉样蛋白,瘦素,亲胰岛素)历史上的困难肽/蛋白表达。
商品名称 商品货号 商品品牌
Beta-Amyloid (1-40), Mouse, Rat A-1007-1 rPeptide
Beta-Amyloid (1-40), Starter Kit A-1150-1 rPeptide
Beta-Amyloid (1-40), Starter Kit A-1150-2 rPeptide
Beta-Amyloid (1-40), Ultra Pure, HCl A-1156-1 rPeptide
Beta-Amyloid (1-40), Ultra Pure, HCl A-1156-2 rPeptide
Beta-Amyloid (1-40), Ultra Pure, HFIP A-1153-1 rPeptide
Beta-Amyloid (1-40), Ultra Pure, HFIP A-1153-2 rPeptide
Beta-Amyloid (1-40), Ultra Pure, NaOH A-1155-1 rPeptide
Beta-Amyloid (1-40), Ultra Pure, NaOH A-1155-2 rPeptide
Beta-Amyloid (1-40), Ultra Pure, TFA A-1001-1 rPeptide
Beta-Amyloid (1-40), Ultra Pure, TFA A-1001-2 rPeptide
Beta-Amyloid (1-40, D23N) A-1013-1 rPeptide
Beta-Amyloid (1-40, D23N) A-1013-2 rPeptide
Beta-Amyloid (1-40, F4W) A-1011-1 rPeptide
Beta-Amyloid (1-40, F4W) A-1011-2 rPeptide