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蚂蚁淘在线 / 品牌中心 / rPeptide / rPeptide/Tau-4G11 Antibody Kit TA-1005/TA-1115-1/50ug

rPeptide/Tau-4G11 Antibody Kit TA-1005/TA-1115-1/50ug

价格
￥6000.00
货号：TA-1115-1
浏览量：127
品牌：rPeptide
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Description
Tau is a family of six isoforms, derived from a single gene by alternative mRNA splicing1. They vary in size from 352 to 441 amino acids (36.8 to 45.9 kDa), and differ from one another in having three or four microtubule binding repeats (R) of 31-32 amino acids each, and two, one or none amino terminal inserts (N) of 29 amino acids each2.

Tau promotes the assembly and maintains the structure of microtubules in neuronal cells3,4,5. While the fetal brain contains a single isoform of tau (Tau-352) the adult brain has several isoforms. Tau is both phosphorylated and O-GlcNAcylated6. The normal brain tau contains 2-3 moles of phosphate/mole of the protein. In Alzheimer disease tau is hyperphosphorylated, containing 3-4-fold more phosphate/mole of the protein than the normal tau7,8 and is the major protein subunit of paired helical filaments (PHF) that form the neurofibrillary tangles (NFT). NFT accumulation correlates with the clinical progression of Alzheimer's disease. Tau 4G11 (TA-1001) is a rPeptide exclusive Tau Monoclonal Antibody that binds 4 out of the 6 Tau isoforms. It specifically binds Tau-381, Tau-410, Tau-412, and Tau-441 which all contain at least one amino terminal insert.

用产品只提供给进一步的科研使用，不可应用于治疗等其他方面。 rPeptide是设在雅典，美国佐治亚州的一家生物技术公司，是一种在阿尔茨海默氏症和帕金森氏病的研究提供研究产品（重组多肽和蛋白质，抗体，试剂）市场的*。rPeptide还提供定制服务的范围从分子生物学，蛋白表达和纯化，13C和15N的多肽和蛋白质的统一标识。 rPeptide有一个专有的平台载体技术，使可溶性肽/蛋白在大肠杆菌中（如淀，β-淀粉样蛋白，瘦素，亲胰岛素）历史上的困难肽/蛋白表达。 商品名称    商品货号    商品品牌 Beta-Amyloid (1-40), Mouse, Rat    A-1007-1    rPeptide Beta-Amyloid (1-40), Starter Kit    A-1150-1    rPeptide Beta-Amyloid (1-40), Starter Kit    A-1150-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, HCl    A-1156-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, HCl    A-1156-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, HFIP    A-1153-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, HFIP    A-1153-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, NaOH    A-1155-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, NaOH    A-1155-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, TFA    A-1001-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, TFA    A-1001-2    rPeptide Beta-Amyloid (1-40, D23N)    A-1013-1    rPeptide Beta-Amyloid (1-40, D23N)    A-1013-2    rPeptide Beta-Amyloid (1-40, F4W)    A-1011-1    rPeptide Beta-Amyloid (1-40, F4W)    A-1011-2    rPeptide