rPeptide/Calmodulin, Wheat (Triticum aestivum), Biotinylated/C-1008-1/

价格
¥5300.00
货号:C-1008-1
浏览量:127
品牌:rPeptide
服务
全国联保
正品保证
正规发票
签订合同
商品描述
Source
Isolatedfromwheatgerm
Description
ThepresenceofCysteine26inWheatgerm(Triticumaestivum)calmodulin(CaM)makesituniquevis-a-vismammaliancalmodulin.IncontrasttomammalianCaMs,whichlackcysteine,thispreparationisidealforapplicationsrequiringbothcalmodulinactivationandresiduespecifictagging.Mono-taggedBiotinylatedlabeledwheatgermcalmodulinatpositionCysteine26isusefulforproteinarrayapplicationsforthedetectionofcalmodulinbindingproteins(CBPs),Westernblotsandotherapplicationsrequiringaconvenientandsuperiorfluorescentlylabeledcalmodulin.Calmodulin(CaM)isaubiquitous,calcium-bindingproteinthatbindsandregulatesamultitudeofproteintargets,manyofwhichareinvolvedintheAlzheimer"sandtheParkinson"spathways1,4.CaMhasamolecularweightofabout17kDa,containing148aminoacids,andpIof3.9.CaMischaracterizedbytwodomains,connectedbyanalpha-helixchain.Eachdomainhasthecapacitytobindtwocalciumions.BindingCa2+ionscausesaconformationalchangeinCaM,makingitavailableforinteractionwithtargetproteins.Hence,CaMfunctionsasanintracellularcalciumionbridgetomediatecellularreactionsandrespondsappropriatelytocalciumionconcentration.InAlzheimer"sdisease(AD),irregularcalciumhomeostasisseemstotriggerCaManditsbindingproteins,toenhanceplaqueformationandneurofibrillarydegeneration,whichresultsincelldeath1.TheincreasedcytosoliclevelsofCa2+inADneuronspromotesCaMbindingandregulationofavailableCa2+/CaM-dependentCaM-bindingproteins,associatedwithamyloidbeta(Ab)formation.Inaddition,theincreasedlevelofCa2+triggersCalmodulintoactivatecalcium/CaM-dependentkinaseIIandprecedeneurofibrillarytangleformation2,4.InParkinson"sdisease(PD),Calmodulinhasbeenfoundtointeract,inacalciumdependentmanner,withAlpha-Synuclein,whichisassociatedwiththeprogressionofPD.CaMwasidentifiedasoneofthesynuclein-interactingproteinsthatregulatesynucleinconformation3.
MolecularMass
16,750Da
Purity
>95%bySDS-PAGEstainedwithCoomassiebluehavingasinglebandatapproximately17kDa;Actualmolecularweightis16,750Da.
用产品只提供给进一步的科研使用,不可应用于治疗等其他方面。 rPeptide是设在雅典,美国佐治亚州的一家生物技术公司,是一种在阿尔茨海默氏症和帕金森氏病的研究提供研究产品(重组多肽和蛋白质,抗体,试剂)市场的*。rPeptide还提供定制服务的范围从分子生物学,蛋白表达和纯化,13C和15N的多肽和蛋白质的统一标识。 rPeptide有一个专有的平台载体技术,使可溶性肽/蛋白在大肠杆菌中(如淀,β-淀粉样蛋白,瘦素,亲胰岛素)历史上的困难肽/蛋白表达。 商品名称    商品货号    商品品牌 Beta-Amyloid (1-40), Mouse, Rat    A-1007-1    rPeptide Beta-Amyloid (1-40), Starter Kit    A-1150-1    rPeptide Beta-Amyloid (1-40), Starter Kit    A-1150-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, HCl    A-1156-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, HCl    A-1156-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, HFIP    A-1153-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, HFIP    A-1153-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, NaOH    A-1155-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, NaOH    A-1155-2    rPeptide Beta-Amyloid (1-40), Ultra Pure, TFA    A-1001-1    rPeptide Beta-Amyloid (1-40), Ultra Pure, TFA    A-1001-2    rPeptide Beta-Amyloid (1-40, D23N)    A-1013-1    rPeptide Beta-Amyloid (1-40, D23N)    A-1013-2    rPeptide Beta-Amyloid (1-40, F4W)    A-1011-1    rPeptide Beta-Amyloid (1-40, F4W)    A-1011-2    rPeptide