AboutInVivoMAbanti-mouseTIM-1(CD365)
TheRMT1-10monoclonalantibodyreactswithmouseTcellimmunoglobulinandmucindomain1(TIM-1)alsoknownasCD365.TIM-1isatypeIcell-surfaceglycoproteinandmemberoftheIgsuperfamily.TIM-1ispreferentiallyexpressedonTH2cellsandhasbeenidentifiedasastimulatorymoleculeforTcellactivation.TheTIMgenefamily,playscriticalrolesinregulatingtheimmuneresponsetoviralinfection.TIM-1isalsoinvolvedinallergicresponses,asthma,andtransplanttolerance.TheRMT1-10antibodyhasbeenshowntoneutralizeTIM-1invivoandreducetheseverityofEAE,inmicestudies.
InVivoMAbanti-mouseTIM-1(CD365)Specifications
Isotype | RatIgG2a, κ |
RecommendedIsotypeControl(s) | InVivoMAbratIgG2aisotypecontrol,anti-trinitrophenol(BE0089) |
RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
Immunogen | Full-lengthmouseTim-1-Igfusionprotein |
ReportedApplications | invivoTIM-1blockade |
Endotoxin |
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Purity |
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Formulation |
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Sterility | 0.2μMfiltered |
Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
Purification | ProteinG |
Storage | Theantibodysolutionshouldbestoredatthestockconcentrationat4°C.Donotfreeze. |
RRID | AB_10949022 |
MolecularWeight | 150kDa |