AboutInVivoMAbanti-mouseIL-23(p19)
TheG23-8monoclonalantibodyreactswiththep19subunitofmouseIL-23.IL-23isaheterodimericcytokinecomposedoftwodisulfide-linkedsubunits,ap19subunitthatisuniquetoIL-23,andap40subunitthatissharedwithIL-12.IL-23issecretedbyactivateddendriticcellsandmacrophages.IL-23hasbeenshowntoenhanceIFNγproductionbymemoryTcells.Additionally,mouseIL-23inducestheproliferationofmemoryTcells(butnotnaiveTcells),whereasIL-12hasnoeffectonmemorycells.MouseIL-23(butnotIL-12)canalsoactivatemousememoryTcellstoproducethepotentproinflammatorycytokineIL-17.IL-23hasbeenshowntobeupregulatedincertainautoimmunediseasesandpromoteimmunityinresponsetosomeviralandmycobacterialinfections.TheG23-8antibodycanspecificallyneutralizeIL-23bioactivitywithnoeffectonIL-12p70bioactivity.
InVivoMAbanti-mouseIL-23(p19)Specifications
| Isotype | RatIgG1,κ |
| RecommendedIsotypeControl(s) | InVivoMAbratIgG1isotypecontrol,anti-horserADIshperoxidase(BE0088) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | Insectcell-expressed,recombinantmouseIL-23heterodimer |
| ReportedApplications |
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| Formulation |
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| Endotoxin |
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| Purity |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| RRID | AB_2754551 |
| MolecularWeight | 150kDa |
| Storage | Theantibodysolutionshouldbestoredatthestockconcentrationat4°C.Donotfreeze. |
