About InVivoMAb anti-mouse CD28
The D665 monoclonal antibody reacts with mouse CD28, a 45 kDa costimulatory receptor and a member of the Ig superfamily. CD28 is expressed by thymocytes, most peripheral T cells, and NK cells. CD28 is a receptor for CD80 (B7-1) and CD86 (B7-2). Signaling through CD28 induces IL-2 and IL-2 receptor expression and T cell proliferation. The D665 antibody is a CD28 superagonist and is most commonly used to induce the expansion of Treg cells in vivo in various mouse models of disease.
InVivoMAb anti-mouse CD28 Specifications
| Isotype | Mouse IgG1, κ |
| Recommended Isotype Control(s) | InVivoMAb mouse IgG1 isotype control, unknown specificity(BE0083) |
| Recommended InVivoPure Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer(IP0070) |
| Immunogen | A20 cells expressing mouse CD28 and a recombinant mouse CD28-Ig fusion protein |
| Reported Applications |
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| Formulation |
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| Endotoxin |
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| Purity |
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| Sterility | 0.2 μM filtered |
| Production | Purified from tissue culture supernatant in an animal free facility |
| Purification | Protein G |
| Molecular Weight | 150 kDa |
| RRID | AB_2819055 |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
