ThePK136monoclonalantibodyreactswithmouseNK1.1alsoknownasCD161b/CD161c,KLRB1,NKR-P1AandLy-55.NK1.1isatypeIIintegralmembraneglycoproteinwithaC-typelectindomainandisencodedbytheKlrb1c/NKR-P1Cgene.NK1.1playsrolesinNKcellactivationanddifferentiation,IFN-γproduction,cytotoxicgranulerelease,andisthoughttobeinvolvedinthegenerationofTh2cells.NK1.1ispredominantlyexpressedasadisulfide-linkedhomodimeronNKcellshowever,itisalsoexpressedonNK-Tcells,ararepopulationofTlymphocytes.NK1.1isonlyexpressedbyC57BL/6,FVB/N,andNZBstrainsofmiceandnotAKR,BALB/c,CBA/J,C3H,DBA/1,DBA/2,NOD,SJL,and129strains.
Isotype | MouseIgG2a, κ |
RecomendedIsotypeControl(s) | InVivoPlusmouseIgG2aisotypecontrol,unknownspecificity |
RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
Immunogen | MousespleenandbonemarrowcellsenrichedforNK1+cells |
ReportedApplications |
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Endotoxin |
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Purity |
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Aggregation |
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Formulation |
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Sterility | 0.2μMfiltered |
Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
Purification | ProteinA |
Storage | Undilutedat4°Cinthedark |
MurinePathogenTestResults |
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