The1D11.16.8monoclonalantibodyreactswithmouse,human,rat,monkey,hamster,canineandbovineTGF-β(transforminggrowthfactorbeta)isoforms1,2and3.TGF-βisamultifunctionalcytokinethatregulatestheproliferationofepithelialcells,endothelialcells,fibroblasts,neurons,lymphoidcellsincludingTlymphocytesandNKcells,andotherhematopoieticcelltypes.TGF-βalsoregulatestheactivitiesofactivatedmacrophagesandthedevelopmentofregulatoryTcells.Additionally,TGF-βplaysrolesinimmunefunction,tissueremodelingandwoundrepair.TGF-βexistsasfivehighlysimilarisoforms(TGF-β1-5)withhomologiesof70-80%.TGF-β1issynthesizedbytheenzymaticcleavageofalongprecursorTGF-β1polypeptideencodedbytheTGFB1genewhichyieldsthematureproteinandtheLatencyAssociatedPeptide(LAP).TheLAPandmatureTGF-β1non-covalentlyassociateduringsecretion.TGF-βisubiquitouslyexpressedbymanycelltypesincludingmacrophagesandplateletswhichexpresshighlevelsofTGF-β.TGF-βsignalinghasbeenshowntoplaysrolesincancer,autoimmunediseases,asthma,heartdisease,anddiabetes.ItsimportanceisillustratedbyTGF-βknockoutmicewhichshowdefectsinhematopoiesisandendothelialdifferentiation,anddieofoverwhelminginflammation.The1D11.16.8monoclonalantibodyisaneutralizingantibody.
| Isotype | MouseIgG1, κ |
| RecomendedIsotypeControl(s) | InVivoMAbmouseIgG1isotypecontrol,unknownspecificity |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
| Immunogen | BovineTGFβisoform2 |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
