TheOKT-8monoclonalantibodyreactswithhumanCD8α.TheCD8antigenisatransmembraneglycoproteinthatactsasaco-receptorfortheTcellreceptor(TCR).LiketheTCR,CD8bindstoclassIMHCmoleculesdisplayedbyantigenpresentingcells(APC).CD8isprimarilyexpressedonthesurfaceofcytotoxicTcells,butcanalsobefoundonthymocytes,naturalkillercells,andsomedendriticcellsubsets.CD8mostcommonlyexistsasaheterodimercomposedofoneCD8αandoneCD8βchainhowever,itcanalsoexistasahomodimercomposedoftwoCD8αchains.BoththeCD8αandCD8βchainssharesignificanthomologytoimmunoglobulinvariablelightchains.ThemolecularweightofeachCD8chainisapproximately34kDa.TheOKT-8antibodydoesnotblockthebindingoftheanti-humanCD8αantibodiesRPA-T8andHIT8a.
| Isotype | MouseIgG2a |
| RecomendedIsotypeControl(s) | InVivoMAbmouseIgG2aisotypecontrol,unknownspecificity |
| Immunogen | HumanCD8α |
| ReportedApplications | invivoCD8+Tcelldepletioninhumanizedmice |
| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
