Cobalt chelates recognize two exposed vicinal histidines. This resin is used in many purifications because this cation provides very good selectivity.High Density Cobalt provides a high amount of available groups allowing for higher binding capacity.The resin is adequate to work in batch or column purifications (Low Flow).

REFERENCES:

• Muñoz-Morales, Emilio et al. “Deciphering the Effect of Microbead Size Distribution on the Kinetics of Heterogeneous Biocatalysts through Single-Particle Analysis Based on Fluorescence Microscopy.” Catalysts 9.11 (2019): n. pag. Catalysts.
• Anderson, Cathy J. et al. “Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase.” Cell Reports 26.7 (2019): 1681-1690.e5. Cell Reports.