This product contains mouse monoclonal IgG1 ascites fluid produced from mice injected with Tyrosine Hydroxylase (TH) purified from PC12 cells.

Volume: 100 µL, 20 µL

Concentration: 1 mg/mL

Clonality: Monoclonal

Form: Ascites Fluid and Purified Available (select your preferred form, size and quantity before clicking "Add to Cart")

Host Species: Mouse

Antibody Isotype: IgG1

Species Reactivity: Chicken, Frog, Human, Lizard, Monkey, Mouse, Rat, Vole, Zebrafish

Applications: ICC, IHC, IP, WB

Immunogen: Tyrosine Hydroxylase purified from PC12 cells.

Protein Name / Synonyms: Tyrosine 3-monooxygenase

Target Description: Tyrosine Hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine and is responsible for converting L-tyrosine to L-dopa. Synthesis of catecholamines is regulated by the interaction of TH with its cofactor, tetrahydrobiopterin (BH4), and the substrates L-tyrosine and molecular oxygen. In humans, four TH mRNA splice variants (hTH1-hTH4) have been isolated, while subprimate species rely on a single form of TH. It is known that the hTH1-hTH4 variants are identical in their catalytic domain but differ in their N-terminal regulatory domains. Importantly, LNC1 reacts with the catalytic domain of TH and thus with all four isoforms of human TH. The role of TH in the synthesis of catecholamine neurotransmitters suggests a connection between the enzyme and a number of neuropathogenic diseases characterized by irregular catecholamine levels, such as Parkinson"s disease, schizophrenia, and dystonia, as well as a variety of cardiovascular diseases.

Gene ID: TH, TYH, EC 1.14.16.2

Physical State: Liquid

Validation and Application Notes

Molecular Weight: 59-63 kDa

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Storage

Aliquot and store at -20 degrees celcius.Stable for 2 years after opening when stored as described.

NOTE

Aves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.

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鸡的概念 在一次会议上，他与同事的一次谈话说服了西蒙博士再次尝试制造这种抗体，但是尝试把鸡作为宿主——鸡在进化上与包括人类在内的哺乳动物完全不同。结果表明:人蛋白抗原具有高度的免疫原性，抗体产量异常高，免疫试剂结合紧密，特异性高。 今天的Aves 从那时起，Aves Labs开创了在蛋白质中寻找高免疫原性肽序列的新算法，开发了针对鸡抗体的新的亲和纯化方法，并开发了许多其他有用的试剂，如BlokHen®阻断试剂和PrecipHen®免疫沉淀试剂。Aves实验室继续开发针对神经特异性抗原和表位标签的新型抗体试剂，以促进神经科学和分子生物学领域的科学进步。