Volume: Purified: 100 µL; Purified Trial: 20 µL; TC Supernatant: 5 mL

Concentration: Purified: 1 mg/mL; TC Supernatant: Lot Specific

Clonality: Monoclonal

Form: Purified and TC Supernatant Available (select your preferred form, size and quantity before clicking "Add to Cart")

Host Species: Mouse

Immunogen: Fusion protein amino acids 1751-1946 (cytoplasmic C-terminus) of human Nav1.7 (also known as sodium channel protein type 9 subunit alpha, neuroendocrine sodium channel, hNE-Na and peripheral sodium channel 1, accession number Q15858)Mouse: 96% identity (190/196 amino acids identical)Rat: 95% identity (186/196 amino acids identical)Shares 66-84% identity with other Nav channels

Target Description: Nav1.7 subunit alpha, or SCN9A, is a member of the voltage gated sodium channel family. It is expressed at the terminal ends of sensory neurons in the dorsal root ganglion (DRG) and in trigeminal and sympathetic ganglion neurons. A major function of Nav1.7 is the generation and conduction of action potentials in nociceptors, or “pain receptors” and thus involved in pain sensation. Changes in Nav1.7 expression have been linked to primary erythermalgia, primary erythermalgia, and Congenital insensitivity to pain

Gene ID: SCN9A NENA

Antibody Registry ID (RRID): AB_2184355

Physical State: Liquid

Validation and Application Notes

Molecular Weight: 230 kDa

NOTE

Aves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.

↑ back to top

鸡的概念 在一次会议上，他与同事的一次谈话说服了西蒙博士再次尝试制造这种抗体，但是尝试把鸡作为宿主——鸡在进化上与包括人类在内的哺乳动物完全不同。结果表明:人蛋白抗原具有高度的免疫原性，抗体产量异常高，免疫试剂结合紧密，特异性高。 今天的Aves 从那时起，Aves Labs开创了在蛋白质中寻找高免疫原性肽序列的新算法，开发了针对鸡抗体的新的亲和纯化方法，并开发了许多其他有用的试剂，如BlokHen®阻断试剂和PrecipHen®免疫沉淀试剂。Aves实验室继续开发针对神经特异性抗原和表位标签的新型抗体试剂，以促进神经科学和分子生物学领域的科学进步。