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Xcess新型高效神经保护分子P7C32014年10月13日03:55 | 新闻印刷版刚刚在上个月的Cell中发表，最近关于神经保护小分子P7C3的 MOA研究具有广泛的体外和体内活性，为研究共享其他常见组织的神经系统疾病，损伤，发育和退行性疾病提供了新的令人兴奋的机会机制。 P7C3 是直接从体内神经发生筛选中鉴定出的无毒，稳定且可口服生物利用的合成小分子。它可以保护齿状回中的新生神经元，并刺激新神经元的生长。它还可以增强老年大鼠的学习和记忆能力。在爆炸介导的创伤性脑损伤（TBI）的啮齿动物模型中，P7C3还可以在损伤后，在神经元细胞死亡发生之前保持轴突的完整性。MOA研究表明P7C3可以结合烟酰胺磷酸核糖基转移酶（NAMPT），这是一种将烟酰胺转化为烟酰胺腺嘌呤二核苷酸（NAD）的限速酶。将活性P7C3化学物质施用至用阿霉素处理的细胞（诱导NAD耗竭），可导致细胞内NAD水平反弹，并免受阿霉素介导的毒性的影响。 如何订购： Xcess Biosciences是一家领先的试剂和服务公司，提供10 mM DMSO溶液和以克计的固体形式的化合物。请访问我们的网站以获取订单信息和其他创新产品。特别是Xcess Biosciences继续向我们的表观遗传调节剂工具箱 （现在我们提供72种独特的化合物）和 泛素调节剂工具箱 （现在我们提供15种独特的化合物）中添加了更多新颖的小分子化学探针 。
Product Information
| Purity: | ≥98% for each compound |
| Storage: | 4oC for 3 month.-20oC for 6 month. |
| Cocktail Formulation: | 5 mM Thiazovivin, 2 mM SB-431542, 0.4 mM PD0325901 and 1 mM CHIR99021 in DMSO. |
Biological Activity:
Extensive studies have shown that individual Rock inhibitor (Thiazovivin), TGFβ inhibitor (SB431542), MEK inhibitor (PD0325901), GSK3β inhibitor (CHIR99021), , and their combinations (TSPC) can significantly enhance reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs). For customers’ convenience, XcessBio has formulated the ready-to-use iPSC-TSPC cocktail containing all four small molecules at optimal concentrations and functionally tested it in iPSC reprogramming.
How to Use:
- In vitro: Dilute the received ready-to-use iPSC-TSPC cocktail at 1:1000 into your iPSC reprogramming medium to make the iPSC-TSPC media for iPSC induction.
Reference:
- 1. Valamehr B, et al. A novel platform to enable the high-throughput derivation and characterization of feeder-free human iPSCs. (2012) SCIENTIFIC REPORTS. 2 : 213
- 2. Li W, et al. Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. (2009) Stem Cells. 27(12):2992-3000.
- 3. Lin T, et al. A chemical platform for improve induction of human iPS cells. (2009) Nature Method 6, 805-808.
- 4. Kawamata M, et al. Generation of genetically modified rats from embryonic stem cells. (2010) PNAS 107, 14223-14228.
- 5. Zhu S, et al. Reprogramming of human primary somatic cells by OCT4 and chemical compounds.(2010) Cell Stem Cell 7, 651-655.
- 6. Yu J, et al. Efficient feeder-free episomal reprogramming with small molecules. (2011) PLoS ONE 6(3): e17557.
- Product Specification:
Kit-iPSC-TSPC_spec.pdf- Product MSDS:
- Kit-iPSC-TSPC_MSDS.pdf
Products are for research use only. Not for human use.
