The Coombs test, also called direct antiglobulin test, is designed to detect immune-mediated erythrocyte destruction which occurs in autoimmune hemolytic anemias, and in some cases with infections and neoplastic disorders. Hemolysis in these diseases is caused by erythrocytes being coated with antibody (IgG, IgM) and/or complement components (C3). Coated erythrocytes are either lysed in the bloodstream and/or removed by phagocytes. The Coombs reagent is an antiserum to IgG, IgM, and C3 prepared in goats. After obtaining the antiserum from the goat, complement is inactivated by heat and then the antiserum is absorbed repeatedly with washed normal erythrocytes. These treatments ensure that the Coombs reagent will not react with normal erythrocytes. However, erythrocytes that are coated with IgG, IgM, and/or C3 will be agglutinated by the Coombs reagent that contains antibodies to IgG, IgM, and C3.
VMRDVMRD于1981年创立，位于华盛顿州普尔曼市，开发和生产兽医诊断检测试剂盒及相关试剂，作为一家快速发展的公司，VMRD致力于保持其以家庭为中心的文化以及诚信和质量的核心价值观。 VMRD was founded in 1981 by D. Scott Adams, DVM, PhD, and currently employs over 50 researchers, lab technicians and support personnel. From its site in Pullman, Washington VMRD develops and manufactures veterinary diagnostic test kits and related reagents for distribution in more than 55 countries. As a rapidly growing company, VMRD strives to preserve its family focused culture and core values of integrity and quality. 产品列表：No.品牌货号名称规格1VMRD15D2Anaplasma marginale MAb (MSP1) IgG3 Isotype0.1mg2VMRDBLV2BLV MAb Ascites gp51 D-D' IgG1 Isotype0.1mg3VMRDPAB-IBRBovine Herpesvirus Type 1 (BHV-1/IBR) Antiserum2ml4VMRDBLV3Bovine Leukemia Virus (BLV) MAb p24 IgG1 Isotype0.1mg5VMRD2E10-H2Canine Adenovirus Type 1 (CAV-1) MAb IgG1 Isotype0.1mg6VMRDCDV-NPCanine Distemper Virus (CDV) MAb0.1mg7VMRDPAB-CPICanine Parainfluenza Virus Type 2 (CPI-2) Antiserum2ml8VMRDCAEP10A1Caprine Arthritis Encehpalitis Virus (CAEV) MAb CAEV-63, CAEV-Co, MVV IgG1 Isotype0.1mg9VMRDPAB-ERVEquine Herpesvirus Type 1 (EHV-1/ERV) Antiserum2ml10VMRDPAB-NCNeospora caninum Antiserum1ml11VMRD1B6Parainfluenza Virus Type 3 (PI-3) MAb p69 IgG2a Isotype0.1mg12VMRDPAB-PCV2Porcine Circovirus Type 2 (PCV-2) Antiserum2ml13VMRD3C9D11H11Porcine Parvovirus (PPV) MAb IgG1 Isotype0.1mg14VMRDF89/160.1.5Prion Protein MAb IHFG IgG1 Isotype0.1mg15VMRD3G9F3Pseudorabies Virus (PRV) MAb gIII IgG2b Isotype0.1mg
