MK-2206 dihydrochloride is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively. Inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins.

Additional Information

Product Name: Also Known As: Catalog No.: Size: CAS: Formula: Molecular Weight: Form: Quality Assurance: Source: Storage: PDF Data Sheet: Image(s): Shipping Method: References:

MK-2206 dihydrochloride

MK-2206 2HCl, 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one

F6160

5 mg

1032350-13-2

C25H21N5O.2HCl

480.39 Da

Lyophilized powder

>98% by HPLC and NMR

Synthetic

Eligible for room temperature shipping. Store at -80°C upon receiving

Download PDF datasheet

N/A

Room temperature shipping

Yan L., et al. (2009) Abstract Number: DDT01-1.

Details

MK-2206 dihydrochloride is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively. Inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. Solubility: > 20 mg/ml in DMSO

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