Rapamycin is an antifungal and immunosuppressant. Rapamycin was originally used an antifungal antibiotic. It is now known as a specific inhibitor of mTOR. Rapamycin binds to FK-binding protein 12 (FKBP12) and forms the rapamycin-FKBP12 complex, which regulates an enzyme that plays an important role in the progression of the cell cycle. Rapamycin and other inhibitors of mTORC1 signaling show potential in treating cancer, adipogenesis, diabetes, tuberous sclerosis, and cardiovascular disease.

Additional Information

Product Name: Also Known As: Catalog No.: Size: Molecular Weight: Species: Source: Stock: Concentration: Quality Assurance: Storage: PDF Data Sheet: NCBI RefSeq: Image(s): Shipping Method: References:

Rapamycin

AY-22989, LCP-Siro, RAPA, Rapamune, Sirolimus, SILA 9268A

F6130

10 mg

914.17 Da

N/A

Synthetic

Powder

N/A

>99% by HPLC and NMR

Eligible for room temperature shipping. Store at -20°C upon receiving; protect from air and light

PDF Datasheet

N/A

(Click image to enlarge)Purity check of Rapamycin by HPLC

Room temperature shipping

1. Corradetti MN, et al. (2006) Oncogene. 25(48):6347-60.2. Foster KG, et al. (2010) J Biol Chem. 285(19):14071-7.3. Malagelada C, et al. (2010) J Neurosci. 30(3):1166-75.

Details

Rapamycin is an antifungal and immunosuppressant. Rapamycin was originally used an antifungal antibiotic. It is now known as a specific inhibitor of mTOR. Rapamycin binds to FK-binding protein 12 (FKBP12) and forms the rapamycin-FKBP12 complex, which regulates an enzyme that plays an important role in the progression of the cell cycle. Rapamycin and other inhibitors of mTORC1 signaling show potential in treating cancer, adipogenesis, diabetes, tuberous sclerosis, and cardiovascular disease.Images(Click image to enlarge)Purity check of Rapamycin by HPLC

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