Ube2V2 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. Ube2V2 is the human homolog of yeast Mms2 and shares 50% amino acid sequence identity. Its main function is to be used in DNA repair. Ube2V2 forms a heterodimer with the human homolog of Ubc13 (an E2). This complex promotes formation of K63-linked polyUb chains.

Additional Information

Product Name: Also Known As: Catalog No.: Size: Molecular Weight: Species: Source: Stock: Concentration: Quality Assurance: Storage: PDF Data Sheet: NCBI RefSeq: Image(s): Shipping Method: References:

6xHis-Ube2V2

MMS2; UEV2; EDPF1; UEV-2; DDVIT1; EDAF-1; EDPF-1; DDVit-1

C3900

25 µg

16.4 kDa

Human

Bacterial recombinant

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol

See tube label

~95% by SDS-PAGE, see datasheet for gel image

Store at -80°C; avoid multiple freeze-thaw cycles

PDF Datasheet， MSDS

NM_003350

(Click image to enlarge)

Coomassie-stained SDS-PAGELane 1: Molecular weight markersLane 2: 5 µg purified 6xHis-Ube2V2

Dry ice shipping

1. Fritsche J, et al. (1997) Biochem Biophys Res Commun 235(2), 407-12.2. Xiao W, et al. (1998) Nuclei Acids Res 26(17), 3908 – 3914.3. McKenna S, et al. (2001) J Biol Chem 276(43), 40120 – 40126.

Details

Ube2V2 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. Ube2V2 is the human homolog of yeast Mms2 and shares 50% amino acid sequence identity. Its main function is to be used in DNA repair. Ube2V2 forms a heterodimer with the human homolog of Ubc13 (an E2). This complex promotes formation of K63-linked polyUb chains. Images:(Click image to enlarge) Coomassie-stained SDS-PAGELane 1: Molecular weight markersLane 2: 5 µg purified 6xHis-Ube2V2

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