SUMO1-3 (small ubiquitin-related modifiers) are ubiquitin-like proteins that can be conjugated to substrate proteins using a cascade of enzymatic reactions. Protein sumoylation can be reversed by the sentrin-specific (SUMO is also named sentrin) proteases (SENPs). In human cells, SENPs have six members including SENP1, SENP2, SENP3, SENP5, SENP6 and SENP7. SENPs mostly reside in the nucleus. They function to generate mature SUMO1-3 from the SUMO precursors and attenuate signals mediated by sumoylation. The SENP1 catalytic domain comprises amino acid from 419 to 644.

Additional Information

Product Name: Also Known As: Catalog No.: Size: Molecular Weight: Species: Source: Stock: Concentration: Quality Assurance: Storage: PDF Data Sheet: NCBI RefSeq: Image(s): Shipping Method: References:

6xHis-SENP1 (catalytic domain)

SuPr-2

H9121

100 µg

26.9 kDa

Human

Bacterial recombinant

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol

See tube label

> 95% by SDS-PAGE, see datasheet for gel image

Store at -80°C; avoid multiple freeze-thaw cycles

PDF Datasheet， MSDS

NM_001267594.1

(Click image to enlarge)

Coomassie-stained SDS-PAGELane 1: Molecular weight markersLane 2: 5 µg purified 6xHis-SENP1 (catalytic domain)

Dry ice shipping

1. Hickey CM, et al. (2012) Nat Rev Mol Cell Biol. 13(12):755-66.2. Yeh ET, et al. (2009) J Biol Chem. 284(13):8223-7.

Details

SUMO1-3 (small ubiquitin-related modifiers) are ubiquitin-like proteins that can be conjugated to substrate proteins using a cascade of enzymatic reactions. Protein sumoylation can be reversed by the sentrin-specific (SUMO is also named sentrin) proteases (SENPs). In human cells, SENPs have six members including SENP1, SENP2, SENP3, SENP5, SENP6 and SENP7. SENPs mostly reside in the nucleus. They function to generate mature SUMO1-3 from the SUMO precursors and attenuate signals mediated by sumoylation. The SENP1 catalytic domain comprises amino acid from 419 to 644.Images:(Click image to enlarge) Coomassie-stained SDS-PAGELane 1: Molecular weight markersLane 2: 5 µg purified 6xHis-SENP1 (catalytic domain)

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