RING-finger 4 (RNF4), also known as Snurf, is an E3 ubiquitin ligase. RNF4 is composed of four SUMO interaction motifs (SIMs) at the N-terminal and a RING domain at the C-terminal. The SIM domains prefer binding polySUMO chains; RNF4 functions to ubiquitinate polysumolyated proteins including promyelocytic leukaemia (PML), which target them for proteasomal degradation.

Additional Information

Product Name: Also Known As: Catalog No.: Size: Molecular Weight: Species: Source: Stock: Concentration: Quality Assurance: Storage: PDF Data Sheet: NCBI RefSeq: Image(s): Shipping Method: References:

GST-RNF4

SLX5; SNURF; RES4-26

K1101

250 µg

21.3 kDa

Human

Bacterial recombinant

20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol

See tube label

~90% by SDS-PAGE, see datasheet for gel image

Store at -80°C; avoid multiple freeze-thaw cycles

PDF Datasheet， MSDS

NM_001185009

(Click image to enlarge)

Coomassie-stained SDS-PAGELane 1: Molecular weight markersLane 2: 5 µg purified GST-RNF4

Dry ice shipping

1. Chiariotti L, et al. (1998) Genomics 47(2), 258 – 265.2. Fedele M, et al. (2000) J Biol Chem 275(11), 7894 – 7901.3. Hunter T, Sun H (2008) Ernst Schering Found Sump Proc (1), 1 – 16.4. Tatham MH, et al. (2008) Nat Cell BIol 10(5), 538 – 546.5. Bruderer R, et al. (2011) EMBO Rep 12(2), 142 – 148.

Details

RING-finger 4 (RNF4), also known as Snurf, is an E3 ubiquitin ligase. RNF4 is composed of four SUMO interaction motifs (SIMs) at the N-terminal and a RING domain at the C-terminal. The SIM domains prefer binding polySUMO chains; RNF4 functions to ubiquitinate polysumolyated proteins including promyelocytic leukaemia (PML), which target them for proteasomal degradation. Images:(Click image to enlarge) Coomassie-stained SDS-PAGELane 1: Molecular weight markersLane 2: 5 µg purified GST-RNF4

>>> 更多资讯详情请访问蚂蚁淘商城