Description

Cultrex®BasementMembraneExtract(BME)isasolubleformofbasementmembranepurifiedfromEngelbreth-Holm-Swarm(EHS)tumor.Thisextractprovidesanaturalextracellularmatrixhydrogelthatpolymerizesat37°Ctoformareconstitutedbasementmembrane.Basementmembranesarecontinuoussheetsofspecializedextracellularmatrixthatformaninterfacebetweenendothelial,epithelial,muscle,orneuronalcellsandtheiradjacentstromaandthatplayanessentialroleintissueorganizationbyinfluencingcelladhesion,migration,proliferation,anddifferentiation.ThemajorcomponentsofBMEincludelaminin,collagenIV,entactin,andheparinsulfateproteoglycans.

TheCultreCoat®24WellBMECoatedCellInvasionAssayprovidesatoolforassessingcellinvasionthroughastandardizedthickcoatingofreconstitutedbasementmembranematrixandisavailableina24wellformat.

Catalog#3480-024-Kincludes:
CatalogNumber	Description	Qty
3480-024-01	CultreCoat®24wellplatewithBMECoatedInserts	1
4892-010-01	CalceinAM	1
3455-096-04	25XCellWashBuffer	1
3455-096-05	10XCellDissociationSolution	1
3480-024-02	20XRehydrationSolutionA	1
3480-024-03	20XRehydrationSolutionB	1

IdentificationofanEGFRvIII-JNK2-HGF/c-Met–SignalingAxisRequiredforIntercellularCrosstalkandGlioblastomaMultiformeCellInvasion
VanessaC.Saunders,MarieLafitte,IsabelAdrados,VictorQuereda,DanielFeurstein,YuanYuanLing,MohammadFallahi,LauraH.Rosenberg,andDerekR.Duckett
Mol.Pharmacol.,Oct2015;88:962–969.
http://molpharm.aspetjournals.org/cgi/content/abstract/88/6/962

Trevigen公司位于美国马里兰州的高科技走廊，是一家有12年历史、成长迅速的生物技术公司，其产品和技术的发展方向主要在癌症研究领域，重点强调细胞凋亡、DNA损伤和修复，以及癌症细胞功能和行为。Trevigen品牌的分销商遍及北美，欧洲和环太平洋地区。关于DNA的损伤分析技术的研究，Trevigen获得美国国立卫生研究院（NIH）的SBIR项目资助。