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Selleck Chemicals/Ki20227/S7688

价格
¥4740.00
货号:S7688
浏览量:126
品牌:Selleck Chemicals
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商品描述
DescriptionKi20227 is an orally active and highly selective inhibitor of c-Fms tyrosine kinase(CSF1R) with IC50 of 2 nM, 12 nM, 451 nM and 217 nM for c-Fms, vascular endothelial growth factor receptor-2 (KDR/VEGFR-2), stem cell factor receptor (c-Kit), and platelet-derived growth factor receptor beta (PDGFRβ), respectively.
Targets
c-Fms [1](Cell-free assay)VEGFR2 [1](Cell-free assay)PDGFRβ [1](Cell-free assay)c-Kit [1](Cell-free assay)
2 nM12 nM217 nM451 nM
In vitro

Ki20227, a novel quinoline-urea derivative, is a c-Fms tyrosine kinase inhibitor. The IC50s of Ki20227 to inhibit c-Fms, vascular endothelial growth factor receptor-2 (KDR), stem cell factor receptor (c-Kit), and platelet-derived growth factor receptor B are found to be 2, 12, 451, and 217 nmol/L, respectively. Ki20227 is also found to inhibit the M-CSFdependent growth of M-NFS-60 cells but not the M-CSFindependent growth of A375 human melanoma cells in vitro. Furthermore, in an osteoclast-like cell formation assay using mouse bone marrow cells, Ki20227 inhibits the development of tartrate-resistant acid phosphatase-positive osteoclast-like cells in a dose-dependent manner.[1]

In vivo

In in vivo studies, oral administration of Ki20227 suppresses osteoclast-like cell accumulation and bone resorption induced by metastatic tumor cells in nude rats following intracardiac injection of A375 cells. Moreover, Ki20227 decreases the number of tartrate-resistant acid phosphatase–positive osteoclast-like cells on bone surfaces in ovariectomized (ovx) rats. These findings suggest that Ki20227 inhibits osteolytic bone destruction through the suppression of M-CSF-induced osteoclast accumulation in vivo.[1]

Selleck Chemicals一直专注于生命科学领域高端试剂的开发与研究,旨在以最优价格为客户提供最优质的科研试剂服务。我们的产品包括抗体,重组蛋白,干扰rna,多肽,小分子激酶抑制剂等。Selleck Chemicals拥有一支热情与活力并存,经验与技术兼备的技术支持与客户服务团队,凭借在生命科学领域的多年研发经验,公司与多达2万多个客户建立了长期稳定的合作关系,其中包括世界各大制药厂,生物科技公司,医院及各大临床诊断实验室,世界各著名高校、研究所以及政府机关。