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蚂蚁淘在线 / 品牌中心 / Selleck Chemicals / Selleck Chemicals/QNZ (EVP4593)/S4902

Selleck Chemicals/QNZ (EVP4593)/S4902

价格
￥7400.00
货号：S4902
浏览量：105
品牌：Selleck Chemicals
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商品描述
DescriptionQNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively.
Targets
TNF-α [1](Jurkat T cells)NF-κB [1](Jurkat T cells)
7 nM11 nM
In vitro

EVP4593 inhibits TNF-a production from murine splenocytes stimulated with LPS with IC50 of 7 nM. [1] EVP4593 (300 nM) entails a significant decrease of amplitude of store-operated currents (approximately by 60%), induced by application of 1 μM thapsigargin in Htt138Q cells, thus prevents abnormal store-operated calcium entry. EVP4593 is able to inhibit the activity of channels containing TRPC1 as one of the subunits, but has no effect on homooligomer channels composed exclusively of TRPC1. [2] QNZ (40 nM) completely abolishes the enhancement of neurite number and length evoked by laminin treatment of the schwann cells. QNZ reduces the neurite length by 61.36% of the schwann cells. QNZ significantly inhibits laminin-induced neurite outgrowth. QNZ also greatly diminishes the neurite elongation after 72 hours culture implying that both initial sprouting and longer term growth and extension seen in response to schwann cells seeded on laminin is mediated by NF-κB. [3] QNZ (10 nM) abolishes LPS-induced up-regulation of CSE expression in rat neutrophil. [4] QNZ (100 nM) blocks the induction effects of GRO/KC on K currents in IB4-negative neurons. [5]

Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
JurkatNH24NZRMcW6jc3WgZZN{[Xl?NVLKVoxQhjFyIN88US=>NFLyRWpk[XW|ZYOgUmYu|rqEIFnubIljcXSrb36ge4l1cCCHQ{WwJI9nKDlibl2=M4jYWVIyPzByMkGz
JurkatMWXGeY5kfGmxbjDhd5NigQ>?MYmzJO69VQ>?MlW2Z4F2e2W|IGPPR{BKdmirYnn0bY9vM{O0OlIyPzByMkGz
neuronsMUDGeY5kfGmxbjDhd5NigQ>?MUmzNFAhdk1?MYjpcohq[mm2IIP0c5JmNW:yZYLheIVlKEOjMjug[Y51enl?M2fZUlIyPzByMkGz
SK-N-SHNX;adZZ1TnWwY4Tpc44h[XO|YYm=NGDpSJA{ODBibl2=NHrqOHpqdmirYnn0d{BVWlCFMT3TeZBxd3K2ZXSgV29EKEOjMjugZ5VzemWwdIO=MnmNlE4ODB{MUO=
neuronsMX7GeY5kfGmxbjDhd5NigQ>?NWjkUXA1OzByIH7NMn22dJJwfGWldDDZRWMyOjhiTWPOJIZzd21iZ3z1eIFu[XSnIITvfIlkcXS7MVKyNVcxODJzMx?=
GABA MS-like neuronsMn;MSpVv[3Srb36gZZN{[Xl?Mlj0NVAxKG6PMnHXdoV{[3WnczDhZo5wem2jbDDTU2MudWWmaXH0[YQh[2GuY3n1cUBmdnS{eR?=NW[5[JRKOjdyOECxNlk>
GABA MS-like neuronsNYmyd2xYTnWwY4Tpc44h[XO|YYm=M2oelExODBibl2= MkTico9zdWGuaYrld{B1cGViboXtZoVzKG:oIHz5d49{d22ncz;heZRweGijZ3;zc41mew>?MV6yO|A5ODF{OR?=
GABA MS-like neuronsMWnGeY5kfGmxbjDhd5NigQ>?NFjEUnoyODBibl2=MYry[ZNkfWW|IHHnbY5oKG6ndYLvcpMh KxbTDj[YxtKGSnYYToM2LveVI4ODhyMUK5

... Click to View More Cell Line Experimental Data

Assay
MethodsTest IndexPMID
Western blot
NF-κB p65 / OPN / Tissue factor / Thrombin ;

PubMed: 29061995

Hep3B-CCN3 cells treated with NFκB inhibitor EVP4593 or Aspirin exhibited a significant down regulation of OPN, TF, and thrombin, and the gels/blots in each group were cropped from different gels and different fields.

VEGF / TNF-α / IL-1β / IL-6 / MMP-2 / MMP-9 / NF-κB p65(Ser536) ;

PubMed: 28693192

Changes in protein expression levels including VEGF, TNF-α, IL-1β, IL-6, MMP-2, MMP-9, active form of NF-κB p65 [NF-κB p65 (Ser 536)] and total NF-κB p65 (NF-κB p65) were demonstrated with western blotting.aP<0.01 andbP<0.05 vs. control. VEGF, vascular endothelial growth factor; TNF-α, tumor necrosis factor α; IL, interleukin; MMP, matrix metalloproteinase; NF-κB p65, nuclear factor-κB tumor protein 65; DMSO, dimethyl sulfoxide; QNZ, 4-N-[2-(4-phenoxyphenyl) ethyl] quinazoline-4, 6-diamine.

29061995 28693192
Growth inhibition assay
Cell viability;

PubMed: 28693192

Change of cell viability was evaluated with MTT assay. **P<0.01 vs. control.

28693192
In vivoEVP4593 (1 mg/kg, i.p.) dose-dependently inhibits carrageenin-induced paw edema in rats. [1]
Selleck Chemicals一直专注于生命科学领域高端试剂的开发与研究，旨在以最优价格为客户提供最优质的科研试剂服务。我们的产品包括抗体，重组蛋白，干扰rna，多肽，小分子激酶抑制剂等。Selleck Chemicals拥有一支热情与活力并存，经验与技术兼备的技术支持与客户服务团队，凭借在生命科学领域的多年研发经验，公司与多达2万多个客户建立了长期稳定的合作关系，其中包括世界各大制药厂，生物科技公司，医院及各大临床诊断实验室，世界各著名高校、研究所以及政府机关。