品牌分类
品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
| Description | PF-6260933isapotentinhibitorofMAP4K4withanIC50of3.7nM,possessingexcellentkinomeselectivity. | ||
|---|---|---|---|
| Targets |
| ||
| Invitro | PF-6260933demonstratesgoodphysicochemicalpropertiesaswellasmoderatehumanlivermicrosomal(HLM)clearance[1]. | ||
| Invivo | Followingoraldosing(10mg/kg),PF-6260933displaysaplasmaexposurethatprovidedfreedrugconcentrationsabovethecellIC50valueforabout4-6hafteradmiNISTrationinamousemodel.PF-6260933hassuitablePKpropertiesinmousetobeusedasatoolinaninvivomodelofdiabetes[1]. |
