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公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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商品描述
| Description | R-7050isacellpermeableTNF-αreceptorantagoNISTandis2.3-foldmoreselectiveforTNF-α-mediatedsignalingthanforthatdrivenbyIL-1β. | ||||
|---|---|---|---|---|---|
| Targets |
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| Invitro | R-7050hasaclearselectivitytowardTNFαandtoaslightlyweakerextenttowardtheLPAreceptorwhichbelongstoaGPCRclassoverIL-1β,tyrosinekinase,orFasreceptorsystems[2]. | ||||
| Invivo | R-7050attenuatesneurovascularinjuryafterintracerebralhemorrhage(ICH)inmice,Upto2hpost-injuryadministrationofR-7050significantlyreducedblood-brainbarrieropeningandattenuatededemadevelopmentat24hpost-ICH.Neurologicaloutcomeswerealsoimprovedoverthefirstthreedaysafterinjury.Incontrast,R-7050didnotreducehematomavolume[1]. |
