Description | PTC596isasecond-generationBMI-1inhibitorthatacceleratesBMI-1degradation.Itinhibitscellproliferationandinducesapoptosisinadose-andtime-dependentmanner.IC50valuesat72hoursrangedfrom68to340nMinmantlecelllymphoma(MCL)celllines. | |
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Invitro | PTC596inducesmitochondrialapoptosisinBMI-1-expressingMCLcellsinap53-independentmanner.MCLSPcellsweresusceptIBLetoPTC596-inducedapoptosis[1]. | |
Invivo | PTC596inhibitsmyeloidleukemiacellgrowthinvivowhilesparingnormalhematopoieticcells[2]. |