PubMed:27820798
TheeffectsofVal-boroPro(2μM,24h)onIL-1βexpressionandsecretioninTHP-1macrophagesasdeterminedbyELISA
27820798 | Invivo | TalabostathasbeenshowntoproducepotentantitumoreffectswhenadmiNISTeredorallyinmultiplemousetumormodels.Val-boroPromediatescompletetumorregressionviaanovelmechanismthatrequiresmorerapidDCtraffickingandsubsequentaccelerationofTcellpriming[3].Intumorstroma,talabostatcandirectlytargetFAPexpressedbyreactivefibroblasts.Talabostatstimulatesinnateandadaptiveimmuneresponsesagainsttumorsinvolvingtranscriptionalupregulationofcytokinesandchemokines[2].Val-boroProisknowntostimulatethetranscriptionalupregulationseveralcytokines,includingIL-1β,IL-6,G-CSF,andCXCL1/KC,inbothtumorsandtumor-draininglymphnodes,andtoincreasethemouseserumproteinlevelsofseveralofthesecytokines,includingG-CSFandCXCL1/KC[4]. |
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